11 Best Affiliate Programs For Food Blogs - Pickled Plum

Covid-19 update Wednesday 22nd April

Good morning from the UK. It’s Wednesday 22nd April and today also marks the 50th Earth Day.

Virus news in depth


Air pollution falls by unprecedented levels in major global cities during coronavirus lockdowns - CNN reports that lockdowns restricting travel and industry imposed to halt the spread of coronavirus have resulted in unprecedented reductions in deadly air pollution around the world, new analysis shows. Major cities that suffer from the world's worst air pollution have seen reductions of deadly particulate matter by up to 60% from the previous year, during a three-week lockdowns period. The Indian capital New Delhi -- which frequently tops the world's most polluted city lists -- saw a 60% reduction in PM2.5 levels from March 23 to April 13 from the same period in 2019. Both New Delhi and the country's commercial center Mumbai experienced their best March air quality on record in 2020. During the initial three-week lockdown period, the number of hours rated as "unhealthy" in New Delhi dropped from 68% in 2019 to 17% in 2020. Over the course of Wuhan's 10-week lockdown, the city experienced its cleanest air quality on record for the months of February and March. The average concentration of PM2.5 plunged from 63.2 and 43.9 micrograms per cubic meter in February and March 2019 respectively, to 36.8 and 32.9 in the same months this year. The World Health Organization considers anything above 25 to be unsafe.

Ramadan in a time of plague: 'The best thing is to stay home, stay quiet' - The Guardian points out that the holy month of Ramadan is scheduled to start this week; the ongoing spread of Covid-19 poses unique questions for Muslims around the world, including whether they can access their mosque to pray, whether fasting is still required during a time of plague and whether they can travel home to visit friends and family (such visits are few and far between for many). Many mosques will be closed, the article says including the Ka’bah, the gold-embroidered shrine in Mecca’s Grand Mosque, as well as the Prophet’s Mosque in Medina and Jerusalem’s al-Aqsa mosque. Abdullah Abu Galous, a 38-year-old hardware shop owner from the Palestinian city of Ramallah, said it felt as if Ramadan had been cancelled. “I would never have thought that a tiny virus could stop us from celebrating the month of Ramadan. It has held more than one billion Muslims throughout the world hostage,” he said. Meanwhile, several Arab newspapers have carried expert assurances that fasting has not been shown to reduce resistance to the virus. Al-Azhar, Egypt’s top Sunni mosque, said last week that coronavirus could not be used as an excuse not to participate unless it was scientifically established that drinking water helps to ward off the disease.

Virus news in brief


Today’s live blogs are The Guardian, CNN unless otherwise specified















Supply chain news in depth


No takers: Hyundai cars sit in U.S. ports as virus keeps buyers away - While Hyundai is one of few global automakers whose production has recovered at home, its exports optimism has been dampened by the severity of the U.S. outbreak, weak consumer sentiment and as rivals have quickly moved to guard their turf. Consignments of cars shipped from South Korea are now sitting in U.S. ports, with dealers slow to take deliveries because of slumping sales and rising inventory, four people with knowledge of the matter told Reuters. The company idled a Tucson production line at home last week for five days, while sister firm Kia Motors (000270.KS) is looking to suspend three Korean plants for a week. And analysts now expect a sharp drop in first-quarter operating profit when it reports results on Thursday and some even forecast a second-quarter loss. “I hope that the situation will recover by the middle of next month. If not, we might have to lay off some people,” said Brad Cannon, general manager of an exclusive Hyundai dealership in California, whose sales are down more than 50% from when the pandemic started. Hyundai runs a factory in Alabama - which is closed until May 1 - but imports are key to meet U.S. demand. Only about half of its vehicles sold in the United States are made in North America compared to between 68% and 85% for Japanese rivals Toyota Motor (7203.T), Nissan Motor (7201.T) and Honda Motor (7267.T), who have also suspended production there till May. The South Korean company makes about 61% of its cars overseas, up from 48% a decade ago. That leaves it vulnerable to overseas factory shutdowns and shrinking demand outside of its home market.

Coronavirus pandemic 'will cause famine of biblical proportions' - The Guardian quotes the chief of the UN’s food relief agency who has said that the world is facing widespread famine “of biblical proportions” because of the coronavirus pandemic and that there is only a short time to act before hundreds of millions starve. More than 30 countries in the developing world could experience widespread famine, and in 10 of those countries there are already more than 1 million people on the brink of starvation, said David Beasley, executive director of the World Food Programme. “We are not talking about people going to bed hungry,” he told the Guardian in an interview. “We are talking about extreme conditions, emergency status – people literally marching to the brink of starvation. If we don’t get food to people, people will die.” Covid-19 is likely to be sweeping through the developing world but its spread is hard to gauge. What appears to be certain is that the fragile healthcare systems of scores of developing countries will be unable to cope, and the economic disaster following in the wake of the pandemic will lead to huge strain on resources. “This is truly more than just a pandemic – it is creating a hunger pandemic,” said Beasley. “This is a humanitarian and food catastrophe.” Beasley took his message to the UN security council on Tuesday, warning world leaders that they must act quickly in a fast-deteriorating situation. He urged them to bring forward about $2bn (£1.6bn) of aid that has been pledged, so it can get to the frontline as quickly as possible. Another $350m (£285m) is also needed to set up the logistics network to get food and medical supplies – including personal protective equipment – to where it is needed, including air bridges where ground transport is impossible.

Supply chain news in brief












Good news section


Taxi driver takes stranded student from Spain to Italy free of charge - CNN reports that an Italian student stranded in Spain due to the coronavirus crisis has been driven more than 1,500 kilometers home, free of charge by a taxi driver. Driver Kepa Amantegi, 22, drove Giada Collalto, also 22, from Bilbao, Spain, to Montebello, near Venice, Italy, after a series of unfortunate events left her stuck. Collalto's struggle to find a way back home included hours on the internet and phone calls with the Italian embassy. She managed to purchase a plane ticket from Madrid to Paris, then to Rome and finally to Venice. But on April 8, she found herself navigating more restrictions at the airport of the Spanish capital Madrid, where a flight attendant informed her she wasn't permitted to board. "I was desperate and angry, my parents were worried but couldn't do anything to help me. I called the embassy and they told to me to send an email. All hotels in Madrid were closed, no public transport to go back to Bilbao," she added. A friend of hers knew a taxi driver in Bilbao -- Amantegi -- and contacted him. "He immediately said he was available to come to pick me up and he drove nine hours from Bilbao to Madrid and back," Collalto said. But once she was back in Bilbao, she learned her apartment was no longer available. Amantegi offered to host Collalto in his family home for the night. "I insisted on paying him but he said, 'I don't want to get advantage of you, I see you are in a difficult situation, don't worry about the cost'," Collalto said, adding Amantegi only asked for a reimbursement of expenses for picking her up in Madrid. (Link)

Donations


Several asked if they can send me $/£/€ via Patreon (in some cases because I've saved them time or money, others for no reason at all). I don't need the cash (that's lovely though) but as you may have read above, food bank charities are getting really hit hard with all this panic buying. Please consider giving whatever you'd have given me to a foodbank charity instead:
UK: https://www.trusselltrust.org/
France: https://www.banquealimentaire.org/
Germany: https://www.tafel.de/
Netherlands: https://www.voedselbankennederland.nl/steun-ons/steun-voedselbank-donatie/
Italy: https://www.bancoalimentare.it/it/node/1
Spain: https://www.fesbal.org/
Australia: https://www.foodbank.org.au/
Canada: https://www.foodbankscanada.ca/
USA: https://www.feedingamerica.org/
Thanks in advance for any donations you give. If there's foodbank charities in your country and it's not listed above, please suggest it and I will include it going forward.
submitted by Fwoggie2 to supplychain [link] [comments]

Lee Kuan Yew Book Review, Part Four: The Pathway to Power

Hey, /singapore! I'm back for one last look at From Third World to First, this time focusing on how and why Lee Kuan Yew remained in charge in Singapore and was able to create a stable mostly-one-party system in a democracy. I've had a lot of fun sharing this review series with you all and getting commentary and perspective from you all. Thanks for reading!
This is part four of a four-part series. If this is your first time seeing this, parts 1-3 provide useful context.
Part one: Growth & redistribution
Part two: You are free to agree
Part three: Race, language, and uncomfortable questions

The Pathway to Power

So far, my review has mostly left out one massive elephant in the room. Lee Kuan Yew was Prime Minister of Singapore from 1959 to 1990. When he stepped down from office, he went straight into a close advisory role, sticking around the government in some official capacity until 2011. How was he in power so long? What was his approach to opposition and to political disagreements, beyond lawsuits? Where did he fall on the scale of democratically elected leader to dictator?
As with every other topic, LKY is pretty candid about this all. The best place to start, though, is likely not with the overt political battles. Instead, I'll focus where he focused early: the unions.
Unions
This section will dive into the weeds a bit more than most of my writing. It's for a good cause, I promise.
In the late 1950s and early 1960s, Singapore had, to put it bluntly, a union problem. Between July 1961 and September 1962, the country faced 153 strikes. In LKY's telling, most unions were under communist control, and all "had turned combative," having learned from British trade unions "all the bad habits and practices of how to squeeze employers for more pay and benefits regardless of the consequences to the company." (83)
So Lee Kuan Yew, ardent reactionary that he was, tore unions down, stripped protections and regulations away, and ushered in a new and gloriously productive era of unfettered capitalism.
Those of you who've followed this review so far won't be surprised to hear that's just about exactly not what happened. This chapter came early in the book, and it's where LKY's personal story started becoming really, really interesting to me. Why? Well, it's when he casually mentioned his political experience before becoming Prime Minister:
He was a legal advisor and negotiator, fighting on behalf of trade and student unions (and, unrelated to our current focus but fun to note, moonlighting as a free speech defender when a university socialist club published a "seditious" article). You might remember the quote from part one of my review, when a Labour party leader emphasized how committed a socialist LKY was. What did that mean when he took charge and faced trouble with unions? As he was urging unions to abandon some destructive practices, he was facing down against policies he was responsible for, protections he had fought for when his country's workers were being exploited, but that were damaging his country enough he regretted his decision.
He cites as an example triple pay on public holidays, which "led to cleansing workers deliberately allowing garbage to accumulate before public holidays to ensure that they would have to work on these holidays." (84) Elsewhere, he cites the trouble of employers investing in expensive machinery to minimize need for workers, leading to "a small group of privileged unionized workers getting high pay and a growing band of underpaid and underemployed workers." (84) With these and related concerns in mind, he went in 1966 to a meeting of union leaders from around Asia, asked them not to "kill the goose whose golden eggs [they] needed," (84) and got to work encouraging changes like pay for performance over time on job.
Union leaders objected. He pushed forward, but "took care to meet the union leaders privately to explain [his] worries... [in] off-the-record meetings [to] make them understand why [he] had to get a new framework in place." (85) That actually worked for most. Step one, then: come up with a careful plan, explain it in private, draw support. Step two?
Well, it's Singapore. One "irrational and ignorant" (85) union leader over cleaners and other daily-paid workers delivered an ultimatum asking for a pay raise and then called for some 2400 cleaning workers to strike. LKY ordered the dispute to arbitration to make the strike unlawful. When the union went on strike anyway, the police arrested the leader and 14 others. The union registrar issued notices of potential deregistration to the union. The ministry of health told the workers they had sacked themselves and could reapply for employment the next day.
And, the next day, ninety percent of the workers applied for reemployment, LKY had the support of the public, and union culture started to shift to a give-and-take. He went first to the union leaders, then to employers, urging cooperation and fairness, and emphasized that "unless [they] made a U-turn from strikes and violence toward stability and economic growth, [they] would perish" (88).
On to step three. In 1968, Singapore passed comprehensive laws covering leave, bonuses, and other points of contention. In 1969, they had their first full year without strikes. In 1972, they established a council between union members, employers, and government to determine annual wage increases. LKY requested his colleague Devan Nair return to Singapore to lead the union congress, and under his lead union delegates decided to focus their attention on setting up co-ops in taxis, supermarkets, insurance, and afterwards a strikingly broad array of industries.
The whole thing, at least in LKY's telling, was a spiraling and mutually beneficial arrangement. As union leaders got experience directing co-ops, they gained greater appreciation for the role of good management. To help "reduce the feeling that workers belonged to a lower order," (91) the government subsidized union land purchases for clubs, resorts, and other facilities. To nurture talent, the unions set up a labor college per LKY's urging, and he encouraged talented students returning from overseas to work in the unions and strengthen them.
Why do I emphasize this in so much detail? Primarily to underscore this quote:
Strict laws and tough talk alone could not have achieved this. It was our overall policy that convinced our workers and union leaders... but ultimately it was the trust and confidence they had in me, gained over long years of association, that helped transform industrial relations from one of militancy and confrontation to cooperation and partnership. (88)
And later, this reminder of his guiding ethos as he discusses the checks and balances of unions:
The key to peace and harmony in society is a sense of fair play, that everyone has a share in the fruits of our progress. (93)
As in tensions around race and language, as he approached the unions Lee Kuan Yew balanced strict, hard policy with the reassurance that he understood his people and wanted to help them--and, we Westerners don't fail to note, a side of authoritarianism. Reason and careful negotiation for most, coordinated and overwhelming force when negotiation breaks down, and pragmatic, prosperity-centered policy in the aftermath. It's a pattern you can see again and again. This pattern is one major reason to focus on the unions. The other is that both LKY and his greatest early rivals had their roots in that movement.
Communists
I:
Disclaimer: I am entirely unqualified to provide a thorough, balanced account of Lee Kuan Yew's rise and the controversies in Singapore's early history. My intent here is to present the story largely as LKY writes it. For other sides of the story, consider this BBC article, Wikipedia on the opposition Barisan Sosialis, biographies of those LKY names as communists in his book: 1 2 3 4 5, a couple of reddit threads 1 2 3 plus a journal articleScihub if you're feeling particularly ambitious. tl;dr: There was definitely strong communist influence in Singapore; some LKY accuses of being communists vehemently deny it and likely shouldn't be considered communist; even these non-communist leftists were heavily influenced by Mao and the Cultural Revolution.
Here's an understatement for you: Lee Kuan Yew was not fond of communism. Understandable, given that China went through the full sweep of the Cultural Revolution as he rose into influence. Throughout his book, he speaks of communists with a fascinating mix of fear and respect.
In his telling, the early history of post-colonial Singapore is framed almost entirely as a struggle between his People's Action Party (PAP) and communists. In the 1950s, there was a sort of uneasy alliance between LKY's moderate wing of the PAP, a left wing headed by Lim Ching Siong, and the underground communist organizations in place in Singapore, all eager for independence from Britain. As soon as the PAP became the majority party in 1959, though, that alliance splintered. By 1961, the PAP expelled its left wing (13 of its 39 members), which became the Barisan Sosialis. That's where the real fun began.
If you ask the Barisan, they were non-communist leftists. If you ask LKY, they were a front organization for communism. He takes evident delight throughout a chapter of his book outlining the rise and collapse of their party. The government was contested through the 60s, in and out of an attempted union with Malaysia. In 1968, though, the Barisan declared Singaporean elections illegitimate and refused to participate, electing instead to take inspiration from Mao and call the people of Singapore to "smash all the trammels that bind them and rush forward along the road to liberation" (Cheng 226). The people did not smash the trammels. Instead, the Barisan left the PAP virtually unopposed, granting it uncontested control of the government, and faded quickly from relevance. LKY mentions that it was this "costly mistake... [that] gave the PAP unchallenged dominance of Parliament for the next 30 years." (110)
From there, as he tells it, communist influence shifted into terrorist attacks and bombings during the 70s and a relentless "hardcore following of some 20 to 30 percent of the electorate" (111), as Maoist organization worked throughout the Chinese-speaking part of Singapore. LKY rushes through this, preferring to more specifically outline the falls of several of their leaders (and a few overt communists). Each spent years to decades in jail or exile, only permitted to reenter Singapore upon cutting links with the party and disclosing all past activity.
That may be too passive. Put more bluntly: LKY tossed them in jail, with British approval but without trial, and makes no secret of having done so. He is extremely open about his willingness to take whatever measures necessary to stop communism. His description of their conflicts sounds, simply, like an all-out war:
We learned not to give hostages to our adversaries or they would have destroyed us. (112)
And:
Could we have defeated them if we had allowed them habeas corpus and abjured the powers of detention without trial? I doubt it. Nobody dared speak out against them, let alone in open court. (113)
And:
They were formidable opponents. We had to be as resolute and unyielding in this contest of wills. ...Their ability to penetrate an organization with a cadre of influential activists and take control of it was fearsome. (114)
And:
Despite ruthless methods where the ends justified the means, the communists failed, but not before destroying many who stood up against them, and others who after joining them decided that their cause was mistaken. (119)
From 1963 to 1989, Singapore detained some 690 people, often holding them for years without trial. They required any political actors to affiliate with parties explicitly to "force [communists] out into the open and make them easy to monitor" (115). LKY spoke of the impossibility of progress while "communists retained their baleful influence" (108). In short, he did everything he possibly could to stamp communism and Maoist influence out of Singapore. Your level of comfort with these decisions will likely depend either on your opinion of communism or your commitment to free expression. Charitably, LKY saw the horrors of the Cultural Revolution and determined to stop it within his sphere. Uncharitably, he saw an opportunity to destroy his opposition and take absolute power, and he took it.
For me, though, far more compelling than his opposition to communism was his commitment to learn from their methods.
II:
See, even while LKY lays out his fight against communism, you hear fascinating hints of respect in his descriptions of them. He describes how the PAP, when they took office, were "sickened by the greed, corruption, and decadence of many Asian leaders" (157), and how a similar disgust led Chinese-school students in Singapore to support communism. They "saw the communists as exemplars of dedication, sacrifice, and selflessness, the revolutionary virtues displayed in the spartan lives of the Chinese communist leaders." (157) Later, when describing his conviction that "candidates must not need large sums of money to get elected" (164), he again cites communists, pointing out that they didn't use money to win votes.
Much earlier, when discussing his own need for security, he mentions that while "threats from racial fanatics [were] unpredictable... the communists were rational and calculating and would see no benefit in [attacking his family]" (5). And return to his description of communists failing. He mentions "the skillful and tough methods of the unyielding communists... were unforgettable lessons in political infighting." (112) When dismissively comparing a later opponent to them, he mentions they were "formidable adversaries... serious men, committed to their cause." (125)
Why am I harping so much on this point? Well, much has been made of Singapore's near–one-party system. From a two-party system like the USA, or the multi-party systems in much of the rest of the developed world, it's hard to picture a setting where one party wins every election, time in and time out, without assuming corruption. Lee Kuan Yew provides an explanation for it, and as with many of his lessons in the groundwork of politics, it comes straight from his encounters with the communists. This next quote is pretty long, but I'm sharing it in full because it strikes me as one of the most important insights LKY provides, one that is relevant for every ideological movement:
We had learned from our toughest adversaries, the communists. Present-day opposition leaders go on walkabouts to decide where they will do well, based on the way people respond to them at hawker centers, coffee shops, food courts, and supermarkets, and whether people accept the pamphlets they hand out. I have never believed this. From many unhappy encounters with my communist opponents, I learned that while overall sentiment and mood do matter, the crucial factors are institutional and organizational networks to muster support. When we went into communist-dominated areas, we found ourselves frozen out. Key players in a constituency, including union leaders and officials of retailers' and hawkers' associations, and clan and alumni organizations, would all have been brought into a network by communist activists and made to feel part of a winning team. We could make little headway against them however hard we tried during elections. The only way we could counter their grip of the ground was to work on that same ground for years between elections.
I emphasize this quote so strongly because it speaks directly to my own frustrations with ideologies. Anyone who steps away from an ideology because they believe something in it is untrue will almost inevitably notice, and grow frustrated, with just how many people brush off those same untruths. Lee Kuan Yew doesn't present a new concept here, but he articulates it clearly and directly: Absolute truth is mostly disconnected from success. Organized ideas thrive; scattered ideas fail. People need rallying flags. They lunge for teams. Truth matters a bit, yes, but much more importantly, what are you doing for people? Good organization beats a good idea every time.
If you want the best ideas to win, organize for them.
Did Lee Kuan Yew have good policy ideas? From my angle, yes. There's nothing remarkable about that, though. Plenty of people have those ideas. What truly sets him apart as a figure worth studying, in my eyes, is not just the quality of his ideas but the way he combines them with a depth of understanding of institutions and power.
And in part, he had his deepest adversaries, the communists, to thank for it.
So how did he do it? Why, 60 years later, does the PAP still hold 83 of 89 seats in Singapore's parliament?
Staying in power
I.
After winning all the seats, I set out to widen our support in order to straddle as broad a middle ground as possible. I intended to leave the opposition only the extreme left and right. We had to be careful not to abuse the absolute power we had been given. I was sure that if we remained honest and kept faith with the people, we would be able to carry them with us, however tough and unpalatable our policies. (111)
Our critics believed we stayed in power because we have been hard on our opponents. This is simplistic. If we had betrayed the people's trust, we would have been rejected. (121)
What do you do, as a new political party struggling to gain a foothold, then an abruptly dominant force, to get the trust of everyday citizens? How do you organize?
One tool LKY used was the People's Association (PA). He intended the association to be a hub, not just of political activity, but of useful community resources in general: literacy classes, technology instruction, cooking courses, so forth. To aid in this, he invited influential community members from "clan associations, chambers of commerce, recreational clubs, and arts, leisure, and social activity groups" (122), and set up more than a hundred community centers throughout Singapore.
Next came the "welcoming" and "goodwill" committees--activists in local communities called up to discuss things like road improvements, street lights, and drains on the one hand, delicate race relations on the other. Successful and eager members of these turned into leadership for community centers and "citizens' consultative committees" who received funds to provide public works, welfare grants, and scholarships.
None of these institutions were explicitly partisan. They were aimed at the maintenance tasks of community life, the uncontroversial but useful background structures. LKY mentions that many wanted to avoid active association with political parties, largely as a holdover from colonial times and threats of retribution. These institutions allowed the government to work with "elders who were respected in their own communities" (123), making it easier to reach out to people at all levels. Recall the time LKY worked with Malaysian community leaders to create plans for education--this structure was the means by which he managed it.
Add government housing to this (with its own "residents' committees", and you begin to see the strength of this soft power: layers and layers of semi-political community figures, helping people day-to-day, working alongside the People's Action Party even when not directly affiliated with them. As LKY puts it, "Opposition leaders on walkabouts go through well-tended PAP ground." (123) He credits his own political strength to public speaking skill, which he took advantage of in an annual unscripted address in Malay, Hokkien Chinese, Mandarin, and English, and in rallies around the country.
Voting another party into power, then, would mean in part needing to figure out a whole new system of organization at all levels. The PAP wasn't shy about using this sort of advantage, either. LKY rather proudly mentions one election where they promised priority public housing upgrades for constituencies that voted more strongly for the PAP, then follows it up with one of those lines that could only come from him:
This was criticized by American liberals as unfair, as if pork barrel politics did not exist elsewhere.
Honest. To a fault.
Viable opposition came in a few districts, eventually. That, too, he aimed to turn to his advantage. He spends time on one opponent voted into one precinct in 1981, a "sound and fury" (124) demagogue who took mostly opportunistic stands and who "probably kept better opponents out" (125). Realizing that some MPs hadn't ever faced serious opposition, LKY says, he "decided he was useful as a sparring partner" (125). There's a great moment, too, when he mentions a "shrewder" opponent who apparently reflected the population better by saying the PAP was doing well, but "could do better and should listen more to criticism." (125) In response, the PAP was respectful, aiming to encourage "nonsubversive opposition."
II.
As much as my American instincts lead me to look at this all and want to talk about how controlling and oppressive the idea of this sort of single-party rule is, I find it difficult to do so without proving too much. The US, after all, has two major political parties and a bunch of nearly inconsequential competitors, choked out by organization and history and election rules. On Singapore's scale, one-party leadership isn't unusual here. My home state of Utah has voted for the Republican party since 1968. Chicago, only a little smaller than Singapore, has been under one party since 1927. Organizing, providing services to encourage people to keep them around, criticizing opposition, and promising to help those who support them sounds like, well, every political party on the planet. And when measuring corruption, Singapore compares rather favorably to the US--and, well, almost anywhere else.
Take one element LKY focuses on: money and special interests in politics. Singapore made voting compulsory in 1959 and has enforced strict spending limits in elections throughout the PAP's time as majority party. LKY mentions that neither communists, nor the PAP, nor opposing parties have ever spent much money to win elections. In 2015, the PAP spent $5.3 million between 89 general election candidates. Sticking with Chicago as a point of comparison, their most recent mayoral elections saw a single candidate raise more.
LKY is dismissive as well of the idea of anchoring ministerial salaries low. He explains: "Singapore will remain clean and honest only if honest and able men are willing to fight elections and assume office. They must be paid a wage commensurate with that men of their ability and integrity are earning for managing a big corporation or a sucessful legal or other professional practice." (166) He points out with distaste the "revolving door" system in the US, where high-paid private sector workers are appointed to posts by the president, then return to the private sector with "enhanced value". Part of avoiding this was the decision to remove most perks and allowances and provide benefits as lump sums. The rest was a gradual process: freezing ministerial wages until 1970, then raising them from S$2,500 to S$4,500 monthly while his own was "fixed at S$3,500 to remind the public service that some restraint was still necessary." (168) In 1995, after periodically raising wages, Singapore fixed salaries of senior public officials at two-thirds of their private sector equivalents.
Despite this relative high pay, he shares several stories of times he persuaded people to take salary cuts for government work: a bank GM making S$950,000 per year who he persuaded to become minister of state at a third that salary; a chief justice who went from making S$2 million a year as a banker to S$300,000 in the court, who according to LKY "accepted [the] offer out of a sense of duty" (218).
III.
Most interesting, for me, is how LKY closes his chapter on maintaining control in the political system:
Will the political system that my colleagues and I developed work more or less unchanged for another generation? I doubt it. Technology and globalization are changing the way people work and live. ...Will the PAP continue to dominate Singapore's politics? How big a challenge will a democratic opposition pose in the future? This will depend on how PAP leaders respond to changes in the needs and aspirations of a better-educated people, and to their desire for greater participation in decisions that shape their lives. Singapore's options are not that numerous that there will be unbridgeable differences between differing political views in working out solutions to our problems. (134)
I get the sense that in aiming to maintain power, as in all else, LKY was a pragmatist. He did not aim to set up a dynasty that lasted generations or seek to obtain glory at all costs. He found a system that suited his country's needs at the time and put it in place, anticipating that Singapore would change as it needed to. Make no mistake: he wielded near-absolute power, and he knew it. But he did not abuse it.

Conclusion

One last question remains to be answered, not about Lee Kuan Yew, but about this review:
Why have I spent 12,000 words and the better part of a month poring over the policy of a tiny country of five million, and a leader who hasn't formally been in charge since 1990? What's my agenda?
Put simply, I think it's worth paying attention to. Not the specifics of the policy, so much: Singapore is a unique country, and solutions adapted to its culture and position are unlikely to translate perfectly to other environments. More than that, I am fascinated by the way LKY's approach cleaves at right angles the modern Western political landscape. Three points stood out from Lee Kuan Yew's achievement in Singapore:
  1. It was not inevitable. It's easy to frame things like this in retrospect as certainties of history, but I honestly think that's the wrong view of Singapore. It came close to collapsing in the 60s, and while it used its unique advantages as a port city to the full, LKY took it where he did with a series of careful, rational decisions. Policy specifics like welfare and health care, measured approaches to racial and political tensions, and the others detailed through the book could have gone a myriad of other ways under different leadership, resulting in a very different city even if it still developed. His political power came because he organized and planned for it.
  2. It was not evil. Growing up, I knew little about Singapore, but what I heard could be summed up as "clean place, pretty developed, freaky authoritarian, canes people, bans chewing gum." I've heard it referred to as "China lite" and generally seen, if not outright dismissal, at least heavy skepticism. I think some of that is unwarranted. Lee Kuan Yew had some 50 years in a position of influence to show his true colors, and from what I can see seems to have spent that time sincerely and single-mindedly focused on his country's welfare. Don't get me wrong, his approach has flaws and clearly doesn't align fully with US values, but I cannot find more to object to in his politics than in any other politician's.
  3. It was not reactionary. I said this before and deliberately emphasize it again. Lee Kuan Yew was not looking to the past and pushing against social change. He stood at the vanguard of his country's growth, mixing traditionally progressive and traditionally conservative ideas in surprising ways. One of the most consistent of LKY's messages was a focus on the future: short-term sacrifices for long-term gain, relentlessly pushing to apply new ideas and change his approach rather than seeking to preserve or return to the past. Framing it as reactionary instead of pragmatic leads to poor predictions and a distorted view.
We focus on political issues through the lens of our own culture. For Americans like me, that means viewing things in terms of constitutional rights, red and blue states with their increasing cultural divide, and confidence that we are positioned neatly at the center of the world. I enjoy looking at Singapore both to see when its challenges and responses mirror US ones and to notice where they diverge. For someone like me, dissatisfied with political systems close to home, not fitting cleanly into any local political subculture, feeling disenfranchised, it serves as both an example and an admonishment.
As an example, it is more personal. Lee Kuan Yew is one of the first politicians I've found who almost always discusses and solves problems in a way that makes sense to me and aligns with my ideals. While there are meaningful criticisms to aim towards him, I am mostly not the one to make them. I admire him and believe the world would benefit if more political movements shared his level-headed approach to difficult problems. If the US had a political party with principles similar to LKY's, I would join.
The admonishment, though, should speak to all who would like to see the world change somehow. I repeat it from above. The sheer frequency of people gaining power only to abuse it should warn against any notion that LKY gained and won influence because he was good or right. He gained influence because he understood influence, and his country was fortunate that he chose to use it for their good. Movements don't win influence because they are true or good. They win because they organize to fill people's needs. So what should you do if you want truth, effective policy, or your ideals to gain ground? Organize. Build structure. Help people.
Thanks for sticking with me through this review! My notes can be found here, for anybody who wants yet more and is curious about Singapore's military, banks, or other areas I didn't touch on. If you're interested in reading the book for yourself, particularly if you'd like to see the extensive foreign policy review that takes up the latter two-thirds or write a more scathing critique, I'd encourage you to go pick it up.
I'll close my review quoting Lee Kuan Yew one last time, this time the final paragraph of his book:
The future is as full of promise as it is fraught with uncertainty. ... That we have succeeded in the last three decades does not ensure our doing so in the future. However, we stand a better chance of not failing if we abide by the basic principles that have helped us progress: social cohesion through sharing the benefits of progress, equal opportunities for all, and meritocracy, with the best man or woman for the job, especially as leaders in government. (691)
Cheers!
submitted by TracingWoodgrains to singapore [link] [comments]

AITA for unintentionally getting a co-worker fired and blacklisted?

TLDR: Did a performance assessment with a new hire. She is a single mom and left her 9 y/o son in her hotel room while we were working. I reported this to our manager due to liability and after returning to the home office this afternoon, was informed her contract had been terminated and she would no longer be employed at our affiliate partners.
This Monday l was in the Midwest evaluating a remote new hire still in her probationary period in my department. While working, we shared small details of our lives that you normally do with new co-workers. She mentioned she was a single mom to a 9 y/o boy and since it was still summer break, she had a hard time finding childcare while she worked. I nodded in sympathy and then she told me she brought him along with her on this business trip to enjoy the hotel amenities and get out of the house.
I paused what I was doing and looked at her in surprise. I asked if she had gotten approval for family travel as it’s allowed, as long as it’s requested in advance and approved by our manager. She told me that she didn’t think it was a big deal and she’s done it before in other companies. I didn’t say anything else and we finished our day at the site.
While at the airport, my manager called asking how the review had gone. I gave him my assessment but told him my biggest concern was outside of the site work and mentioned what she had told me. I also expressed my concern over leaving a young child alone for so long. My manager agreed and told me this was a possible liability issue for the company. He said he needed to speak with HR department after our call. I gave him the rest of my assessment and then boarded my flight when it was called.
Today, I arrived at our office for a weekly in-person team meeting. My manager informed us that the new Midwest hire’s contract had been terminated. He added that she would not be receiving a referral and that she was now blacklisted from working on partner company projects.
After the meeting, a few colleagues asked me what happened. I summarized the trip and a couple of colleagues, also single mothers, said I shouldn’t have ratted her out because she most likely didn’t have any other option, and now she was no longer employable in our field. I told them I didn’t expect the consequences to be so severe, but I still had to report what she did because of liability. They disagreed and said I should’ve been more sympathetic to her situation.
Am I the asshole for reporting her transgression?
ADDITIONAL EDIT to answer repeat questions.
Thank you to everyone who’s given judgement and for all the constructive comments. To those who have attacked me personally based on my post, fair enough.
  1. A lot of people are assuming that the new hire was poor or at least too poor to hire childcare. I never wrote that she was poor, only that she had a hard time finding childcare because of summer break. I’m not trying to be elitist, but to qualify for our job, you need a graduate degree or a BSN with at least a couple of years of experience. The new hire certainly has options with other companies not affiliated with our current one or its partners. Any major health network or any large private clinic certainly has openings for what we do with or without a referral.
  2. In regards to corporate loyalty, me, my coworkers, and her are all contractors. We work for ourselves and we pick and choose contracts that we want to take. Once your contract is up, you move on. I could care less who the higher ups are as long as I get a fair evaluation at the end of my contract.
  3. As for HR policy regarding employee information. My field review summary is not privileged information among departmental co-workers who are also field reviewers. This wasn’t water cooler gossip. This was me giving a factual account of what occurred to people who perform the same function that I do. The fact that 2 co-workers thought I was an asshole is a result of this discussion.
  4. Some have asked what I do for a living. In broad terms, my co-workers and I audit clinics, hospitals, and insurance companies to be sure no fraud is happening on either end, and that government laws are followed in regards to procedures and practices. It’s literally our job to be meticulous in following and enforcing established policies.
EDIT for Clarifications
  1. She knew about the travel policies and needing approval. We are all trained on company SOPs as contractors for several weeks before being certified. Once certified, we’re field reviewed and if approved are assigned work projects as remote workers.
  2. My role as a field reviewer was to assess her on her work ethic, site task abilities, and adherence to our SOPs including travel guidelines. I’m not allowed to give feedback to her as it’s her assigned mentor’s job to discuss strengths, weaknesses, and how to improve because they work one on one with new hires closely. I’m a essentially a proctor overseeing a field test.
  3. I’ve never met her or spoken with her or her son before this past Monday and only know what she mentioned in passing.
  4. Her mentor and my manager would have learned she was traveling with someone eventually because the hotel receipt lists the room service menu items purchased. There no possible way food could have been delivered to her room while she was at work with me without someone else ordering it.
  5. “Outside of site work” refers specifically to the tasks we do while at the clinic but doesn’t mean she isn’t evaluated for following guidelines while offsite during travel.
submitted by perpetuallypolite to AmItheAsshole [link] [comments]

If you truly want to secure the welfare of the people you fight and protest for, you must strike at the root of the cause- our constitutions of government-for change to happen.

To My Fellow Americans:
Where is your patriotism? Your “proud” courage? Your integrity? Your humanity?
Why do we antagonize further division: do we not dishonor our name-”united”- by doing so? We have strayed further apart as a nation: we have allowed our superficial differences -race, religion, political affiliation, opposing opinion- to cast aside our brothers and sisters; and cloud our judgement.
Do you fail to realize the suffering, you cause or prolong, of your fellow patriots? Spinning wildly in circles, contributing to a never-ending cycle rather than changing the narrative?
How many more years will it take for us to wake up, if not now? For us to abandon our materialistic habits we hope will fill the belly of your soul? Why have we denied the warmth of conversation? Positive, effective communication is the crop we must grow to fulfill the liberation our spirit seeks.
Yet we have ignored its importance, perpetuating pain rather than support as a consequence: we have prolonged the deprivation of life -which depends on physical, emotional and spiritual health- liberty, and property.
I will no longer remain silent while the country and people I love experience such cruelties.
I will no longer stand idly by while thousands of Americans are overcharged for prescription drugs and hospital bills. Billing and insurance companies cost private insurers and providers $248 billion in excess: the top twenty-five percent of pharmaceutical companies report profit margins of twenty-two percent; $40 billion going to sales and advertising instead of research for new drugs. The denial or prevention of healthcare for our citizens is in violation of their right to life.
I demand change, the mending of a broken system to better accommodate the needs of the people. We have the power to centralize a claim system; reducing third party costs: we have the power to reward and shift focus to efficient, affordable, quality care for all patients; to create a national, transparent set of payment requirements, integrate care networks: we have the power to impose a windfall tax on drug companies charging excessive prices and return their profit to consumers.
How much longer will you watch your fellow citizens go without or be crippled under the cost of healthcare? I will no longer stand idly by while my brothers and sisters go without shelter or food. Are we really solving homelessness by placing bars on benches, spikes in front of stores; or are you fueling the cycle of poverty and crime? Why? Do you believe it is of their own will? Are you fearful of your tax dollars going to waste as the resources provided will be manipulated and taken advantage of?
We are so quick to tell a person in an unfortunate circumstance to be strong and climb up through hard work and dedication, yet lack the instruction or guidance to do so. Who are you to deny your brothers and sisters the opportunity to reclaim their life when they have the will to change but do not know the way?
We have the resources to construct Tiny Home Neighborhoods for twenty times less than a single shelter, involve community volunteers and homeless resident organization, and provide support for those actively participating and committing to change.
I will no longer stand idly by while our youth, the future of our nation, are cheated out of a proper education. The corrosive nature of our system lays evident in the 2.1 million dropouts from age 16-24; yet we continue to ignore the interest and curiosities of the students and force certain subjects irrelevant to mental and physical self-management required for a healthy, rewarding life.
Do we not progress by teaching our future leaders all knowledge of the subject they chose to pursue as well as the keys to a liberating life?
We have the funds to establish a national education standard; to teach accurate, factual information related to a class; progress at the student’s pace; introduce mindfulness breaks, shorter days, and community involvement; to rid homework and standardized tests. Why do we refuse to change our approach and listen to our future generation’s needs.
I will no longer stand idly by while my fellow patriots are stripped of their humanity and subject to cruel and unusual punishment. Is it not our goal to rehabilitate the brothers and sisters we’ve failed to support?
Why are we so quick to deem offenders as evil, vile creatures; deny the complexity of our nature; when we have taught them violence and cruelty?
Is it not cruel and unusual punishment to be treated less than a dog? Why have we not bestowed the punishment all men must face; the demons he has avoided; in its stead?
Strip him of his life, but give him a new one- change and restrict his schedule to reflect positive growth; guide him, teach him how to self manage his mind, body and spirit when he is ready and committed- and reward his success and progress with increased access to job, education, and leisure classes; allow offenders to hug and touch their loved ones under supervision. Is it not a fair, worthy endeavor to face the inner turmoil and change for the better?
Have you forgotten their families? Do you look away while innocent citizens are sacrificing their livelihood for the welfare of their incarcerated loved ones?
We have turned a blind eye to the $1.4 billion in fines from bail bond companies; the outrageous charge of $24.95 for a fifteen minute phone call specialized phone companies require; the $13,000 in court fines and fees on average; the substantial mark-ups or added service fees they are forced to pay approved vendors for restitution.
We house 2.3 million people for $80 billion per year in correctional facilities, spend one hundred times more than the private industry’s profit on payroll for correctional employees, and increase recidivism through strict probation- which currently 3.6 million Americans are subject to.
Creating a truly supportive community that supports self-management and respect can decrease repeat offenders and save $80 billion per year. We must tackle the root behind their actions and sentence those guilty of alcohol or drug abuse to rehabilitation, detoxification, and possible community service or jail time.
I will no longer stand idly by as police brutality divides my fellow citizens and the executive branch‘s irresponsibility. My brothers and sisters are endangered because of lack of national police training and conduct standards.
Is it not against their oath of honor by betraying public trust?
We have the power to end the cycle; to demand entry tests determining ethical, moral, psychological, and physical aptitude; to demand field training as a requirement for all officers of the law before they gain authority which is to include multiple real-world scenarios, nonlethal versus lethal use of force, recognition of mental illnesses, negotiation techniques, the ability to remain calm in stressful situations, military grade threat level assessment, use of the Fitzpatrick Scale to describe skin tone, and public relations and renew every two years.
We have the resources to demand the required use of body and dash cameras throughout shifts; investigations of reported lethal or improper use of force as well as violations of the code of conduct. If found guilty of interfering with body or dash camera footage, intentionally turning the cameras off, or in violation of police conduct, then they shall be permanently suspended, immediately terminated, and possibly serve time in a correctional facility.
I will no longer stand idly by as the jealousies and vices of those trusted to represent the will of the people steal my fellow Americans’ power and destroy our great experiment. 
Has the continual imbalance of the Legislative, Judicial, and Executive branches and the division of our nation caused by our outdated two-party system not proven to be evident?
Super-PACs donate unlimited amounts of money to candidates so legislation benefits them and their agenda: Congressional members sneak in selfish, unnecessary expenditures to the bottom of bills: Cabinet members align their agenda with the president since he owns their seat: Supreme Court members sitting for life, stifling progress by denying fresh, current ideologies and are influenced by party affiliation rather than the Constitution: Lobbyists manipulate and bribe congressional members to push legislation, voting rights denied to our citizens, is this not against the fundamentals of our experiment?
Have you forgotten the power delegated to you upon the absence of the federal and state government; the right to alter the constitutions of our government?
We must establish an equal platform for all candidates to share their policies and plans in detail and expel the two-party system; encourage transparency through fact-checking; introduce term and age limits; use independent experts to review legislation being written to ensure the well-being of the people is not jeopardized; overturn executive orders when both the Cabinet and Supreme Court agree it is in violation of the Constitution or the people’s rights; allow the boards of departments to appoint their heads rather than the President selecting unfit friends for the seat; allowing the Cabinet to also select possible Supreme Court judges and imposing a twenty-five year term limit and an age limit of 60.
We must improve voter access by expanding early voting to 45 days nationally, automatic registration with issuance of identification or driver’s license at age eighteen, creating disable friendly voting stations, allowing secure online and mail in voting, removing Election Day or declaring it a holiday, and educate lour citizens on the importance of voting.
I will no longer stand idly by as my neighbors sacrifice their health and livelihood to earn a living by overworking. Is it not robbing our brothers and sisters from family and a healthy mind?
We must demand national work requirements including a maximum work week of 40 hours, flexible scheduling, 6 hour shifts with 8 hour shifts as overtime, 10 hours as double time, and declaring 12 hour shifts illegal; mandatory paid leave of 10-14 days, mandatory parental leave of 6 months; establishment of a $13 per hour national minimum wage as well as Universal Basic Income.
I will no longer stand idly by as the world I love withers from climate change threatening the eradication of humanity itself. 
We have the resources to demand mitigation of greenhouse gases, increase use of electricity and clean energy, maximize energy efficiency, restore and conserve ecosystems, localize farming to discourage waste, build strong, intimate relationships between farmers, businesses, and consumers.
I will no longer stand idly by as nuclear weaponry and other weapons of mass destruction endanger innocent people. We must demand the eradication of all nuclear weaponry throughout the world: We do not want to die from unchecked emotions and issues from our own or other countries. I will no longer stand idly by as my nation is not enlightened about our feeble government that threatens the tranquil enjoyment of our rights. I ask you to stand with me, educate those willing to listen, unite to change the course of our nation and end the prolonged unnecessary suffering of millions of Americans- sons,daughters, brothers, sisters, mothers and fathers- our constant bickering perpetuates. We must stand united in cause and alter the constitutions of our government, for it is the root of the problems we face. Will you stand united with your fellow patriots; now that you know our nation’s future is in your hands? Will you cast away your differences of opinion and band together to pull out the roots; to look out for your brothers and sisters’ right to life, liberty, and property; to guide and support each other and strengthen our fraternal affection? 
Or will you further divide and betray your people, your nation, for your own selfish vices? Will you deny the love of your community and accept materialistic ventures in its stead because you believe the hole in your spirit will be fulfilled?
If you have any courage, integrity, patriotism, or humanity, please stand with me; defend and support your fellow Americans and their rights to life, liberty, and property; ensure our children’s futures and serve as a city upon a hill. 
Please, wake up America.
We need you more now than ever.
 Sincerely, Your fellow, and probably overly concerned citizen. 
P.S. Sorry for the length. Had a lot to get out since I usually hold my tongue about stuff like this, but I’m tired of staying silent while the people I love turn against each other over lack of education and some superficial ass differences. If you consider yourself a person of reason; or a person who forms their desires in accordance with reason, but fail to receive matters of fact from others to heart or attempt to understand principles differing from your own, you’re nothing short of fucking useless.
submitted by jonswifteatsbabies to self [link] [comments]

Online Pharmacies and Telemedicine

Not a day goes by when our email inboxes do not fill with advertisements for prescription drugs. Many of these emails promise to deliver drugs of all classes by overnight courier without a prescription. While there are legitimate online pharmacies, and the practice of telemedicine or cyber-medicine is gaining acceptance, this change in the way medicine is being practiced is rocking the foundations of the medical establishment. Being able to consult a doctor online, and obtain prescription drugs delivered to your doorstep by UPS has broad social and legal implications. The Internet facilitates making drugs available to those who may not be able to afford to pay US prices, are embarrassed to see a doctor face-to-face, or are suffering from pain, the treatment of which puts most doctors in direct conflict with the 'war on drugs' but on the other hand there is the question whether these pharmacies make drugs available to recreational drug users without the oversight of a licensed medical practitioner.
The Need for Alternatives
Medical care in the US has reached a point where it is expensive and impersonal which has caused the consumer to become generally unsatisfied with the medical establishment as a whole. Examples include the huge differences between the cost of drugs in the US and Canada, long wait times in US pharmacies, and poor service in general. Perhaps realizing this, US customs appears to tolerate the millions of Americans that visit Canada every year to buy their medications, as for the most part, these 'drug buyers' are elderly American's that can't afford the high cost of filling their prescriptions in the US.
Rather than to travel to Canada or Mexico millions of Americans are now turning to the Internet for both their medical needs. Telemedicine (or cyber medicine) provides consumers with the ability to both consult with a doctor online and order drugs over the Internet at discounted prices. This has resulted in consumers turning to online pharmacies for their medical needs, and in particular pharmacies with a relationships with a physician, which allow the consumer to completely bypass the traditional brick and mortar pharmacies, with the added benefit of having their physician act as an intermediary between the consumer and the pharmacy. According to Johnson (2005) this is as a result of consumers becoming very dissatisfied when it comes to dealing with both brick and mortar pharmacies and medical practitioners. As Johnson, notes, "Consumers are more likely to know the name of their hairdresser than their pharmacist." When Johnson (2005) rated the various professions within the health care system, he found that pharmacists had the lowest interaction with their patients than did any other group. Today, as a result of this "consumers are buying 25.5 percent of their prescriptions online, opposed to 13.5 percent of which are picked up at a brick and mortar pharmacy" (Johnson 2005).
Drugs and Society
What has brought so much attention to online pharmacies is that it is possible to obtain just about any drug without a prescription online. Many of these prescriptions are for legitimate purposes purchased through an online pharmacy because the buyer is too embarrassed to visit the doctor or for other reasons including the unavailability of FDA approved drugs to the consumer. These drugs may include steroids that due to their misuse and being classed as a classed a category three drugs, are seldom prescribed by physicians. These drugs have a useful purpose to those suffering from any wasting disease such as AIDS, they also play a role in ant-aging (FDA, 2004).
The Doctor Patient Relationship
Today a visit to a doctor is generally brief, much of the triage it is done by a nurse or a nurse practitioner with the doctor only dropping in for a few minutes, if at all. In many cases the patient is seen by a nurse practitioner. One of the arguments against telemedicine or perhaps a better term is cyber-medicine, is that the doctor does not have a physical relationship with the patients and thus is in no position to make a diagnosis, and thus can not legally prescribe drugs.
Ironically when one compares the work up that one has to go through to consult with an online physicians and compares this to a face-to-face visit with a brick and mortar doctor, one finds that the online physician, in many cases, has a better understanding of the patient's medical condition than does the doctor who meets face-to-face with the patient. In most cases before an on-line a doctor prescribes any type of medication they insist on a full blood workup they may also require that one has additional tests performed, for example.
The AMA, the federal government, and various states claim, however, that it is illegal for a doctor to prescribe drugs without a valid doctor-patient relationship. While there are no laws at present that outlaw online pharmacies, various states have enacted legislation, or are in the process of enacting legislation to prohibit a doctor from prescribing drugs to a patient that they have not seen face to face. Some states also require that the doctor that prescribes the drugs be licensed in their state. This alone could hamper the development of cyber-medicine. According to William Hubbard (2004), FDA associate commissioner "The Food and Drug Administration says it is giving states first crack at legal action, though it will step in when states do not act" (FDA, 2004).
Internet Pharmacies
The reason that email boxes around the country fill up with offers to supply drugs of all kinds, at reduced prices, without prescriptions, and more is because people buy them as the billions of dollars the drug companies are making each year attest to. The Internet has become the drug store of choice for many.
Categories of Internet Pharmacies
Internet pharmacies are generally acknowledged to be comprised of the following five categories:
Internet pharmacies can be divided up into five different categories, as follows:
Licensed online pharmacies with a no medical affiliation.
Licensed online pharmacies with a medical affiliation
No record online pharmacies (NRP)
International online pharmacies (IOP)
Licensed compounding pharmacies
The licensed online pharmacies with a no medical affiliation are of course Drugstore.com, CVV, and others. They all require a prescription from a licensed doctor that the patient has a doctor patient relationship with. The prescription can be called in by the doctor.
The licensed online pharmacies with a medical affiliation often depend on a broker. The broker collects your medical information, and then assigns your case to one of their networked physicians. Many of these networked physicians are willing to prescribe pain killers as they believe that it is only through the use of these drugs that some people can live a harmonious life.
A Government Accountability Office (GAO) Committee on aging held in June 2004 found that "Unlicensed international pharmacies do not require a prescription, and are generally located off shore." No prescription pharmacies can be found all over the world. Many of these sites have come under controversy as in some cases all it takes to have that prescription delivered to you by next day air, is to fill out a questionnaire online.
A study conducted by Henkle in 2002 to ascertain how easy it would be to obtain drugs over the Internet found that "37 of the 46" pharmacy required a prescription from a licensed doctor. The emphasis was on the prescription and not on the doctor. Henkle (2002) in fact notes that some sites offered to recommend a doctor." Henkle (2002) was able to obtain prescription drugs from nine sites outside the US during the study, without a prescription.
Online pharmacies with a doctor affiliation
There are a number of online pharmacies, with a medical affiliation is that take great pain to differentiate themselves form unlicensed overseas pharmacies. These pharmacies, stress that they are "American based companies that provides consumer's easy access to FDA approved online prescriptions over the Internet and are quick to point out that "An online consultation can be just as relevant as an in-person consultation." It is interesting to note that many of these online pharmacies also point out that "While they are committed to making access to online prescriptions easier, they believe that the Internet can not replace the importance of regular doctor visits to fully evaluate your health and any medical conditions." Many of these online pharmacy sites also makes a wealth of drug information available on its web site that enables the consumer to educate themselves on drugs that may have been prescribed. The Internet has for all intensive purposes is quickly replacing the brick and mortar base physician as a patient's primary health care provider.
A sales pitch, of course, or is it? Most of the legitimate online pharmacies ensure that they comply with state and federal regulation. The doctors are licensed in all 50 states and their pharmacies are too. These legitimate Internet pharmacies cater to those that are looking for a better price; for some it comes down to making the choice of eating cat food on crackers in order to afford their medications because of the high US drug prices. In other cases patients resort to cyber-medicine to avoid the embarrassment of having to deal with a physician or pharmacy that may be judgmental. Many of these online pharmacies will arrange a consult with a licensed, medical doctor over the phone and will then fill the prescription accordingly.
submitted by PresentType to inompharmaciesforsale [link] [comments]

2020 Psychedelic Industry Insights Report

By: Nikita Alexandrov BChem, MBA - CTO, ThinkMyco
Jan 8th, 2020
2019 was a pivotal year in the psychedelic industry with US decriminalization actions, two companies receiving FDA breakthrough status for psilocybin, funding of the $16M Johns Hopkins Psychedelic Research Center, The US Defence Department starting their rumored $20M+ Focused Pharma psychedelic science program and the movement of top universities into research and clinical trials. With the explosion of the more than $100M dollars worth of investable psychedelic opportunities in Q3 2019, the collapse of high quality cannabis investments, one of the best Decembers on record and a potential $1B scale psychedelic IPO - 2020 will be the year of psychedelic investment.
The movement in the field recently is just a blip compared to what is to come, this industry has been brewing for the last few decades. Big Pharma has failed when it comes to new approaches to brain and central nervous system treatment. Due to poor understanding of mechanisms, complex clinical trials and systematic side effects, Neuro drugs have half the success rate of all Pharma projects, which caused most of the big players to reduce or cut their Neuro programs in the last decades. Recently, engagement is exploding with new clinical legislature supporting Neuro and the recent approval of 3 potentially blockbuster Neuro drugs in the last 2 years,
Q2 2019 saw a record of over $320M in investment into Neuro drug development. Interestingly enough an influential group of ultra-high net worth individuals including PayPal founder Peter Thiel funded the psychedelic holding company Atai Lifesciences which went on to fund Compass Pathways and continues to fund commercial efforts in this field. Atai Lifesciences recent movements are a familiar story of acquisition and consolidation in an emerging market which will be a common theme in the future of the psychedelic industry. In 2019 Atai Lifesciences acquired Perception Neuroscience and GABA Therapeutics for their next generation tranquillisers. Last week, Atai also acquired NeuroNasal, a non-psychedelic company creating a concussion nasal spray. In partnership with pharma, Atai's recent launch of EntheogeniX, an AI based psychedelic drug discovery platform, shows that Atai is serious about making investments into the fundamental research required to continue being an industry leader in the long-term. It is rumoured that Atai has made a number of cash investments recently, so new partnerships and acquisitions should be expected in the next months.
The collapse of investable cannabis opportunities are driving investors comfortable in stigmatised industries and binary risk to the table with big pharma, cutting edge science and huge unmet market needs to create a perfect storm of opportunity.
Highlight:
Investors seek 'mega blockbuster' drugs as neuroscience undergoes renaissance
How big is the Psychedelics Industry?
Historically, the psychedelics industry has been fragmented with around $60M worth of companies in the last 20 years, many of which were not sustainable. The current industry is around $220M+ worth of investments, dominated by the Peter Thiel backed Atia Lifesciences at $100M+ and Compass Pathways at $50M+, followed by Mind Medicine at $10M+, Fieldtrip Ventures at $10M+ and then a 10-25 early companies in the range of $2.5-10M each. The $220M+ worth of investable deals have only existed since the public formation of Compass Pathways in 2016, with the majority leaving stealth mode in 2019.
Highlight:
Transforming psychedelics into mainstream medicines
How big is the Psychedelics Market?
The psychedelics market is emerging while highly coupled to clinical/regulatory events and is split between recreational and medical psychedelic markets:
Recreational: $8-19.2B
Calculated from cannabis market and comparable usage prevalence as well as demand size economics.
Medical: $373B+
Calculated from the main markets addressable by psychedelic therapeutics (neurogenics market): mental health drugs, therapy spending, neurodegeneration drugs and cognitive enhancement.
Highlight:
Analysis of the Psilocybin Pharmaceutical Market
Who are the players?
Atai Lifesciences - German based, Global psychedelic pharma holding company formed by ultra-high net worth individuals and big pharma, $100M+
Compass Pathways - London based psychedelic giant, Atai's bet on psilocybin as an approved drug for depression, $50M+, IPO 2020
Usona Institute - A Wisconsin based non-profit powerhouse competing with Compass Pathways to approve psilocybin for depression.
Mind Medicine - Toronto based ibogaine derived addiction drug development company taking their lead candidate 18-MC through the clinical approval process, $15M+, RTO in 2020
Eleusis Benefit Corporation - New Orleans based discovery/clinical stage Psychedelic pharma company supported by industry scientists, raising $25M
FieldTrip Ventures - Toronto based, Aurora backed magic mushroom research and development company building clinical and production infrastructure, raising $12M+
ThinkMyco - Vancouver based holding company developing disruptive mushroom production technology and next generation therapeutics, raising $5M+
Gilgamesh Pharmaceuticals - Psychedelic drug discovery company affiliated with the Atai owned Perception Neuroscience and Columbia University, raising 10M+
Universal Ibogaine - Vancouver based Ibogaine clinical development company franchising the world's most advanced ibogaine clinical model, raising $10M+, RTO in 2020
PsyGen Labs - Alberta based psychedelic mass production and clinical research company with highly experienced production chemists $8M+
Entheogen Biosciences - Vancouver based company pursuing psilocybin and DMT based drug development, raising $3M, IPO in 2020
Salvation Botanicals - A Vancouver based company touting a private controlled substances site license and supporting clinical research, raising $10M+, RTO in 2020
Numinus Wellness - Vancouver based wellness company building testing as well as clinical infrastructure, partnered with Salvation, raising $5M+, RTO in 2020
Cybin Corp - Toronto based research and development company building drug development and production infrastructure as well as nutraceutical assets in legal jurisdictions, raising $3M
Emerging Players - There are a number of emerging players, around $35M+ in emerging deals in Q3 2019 which have not passed due diligence.
Clinical:
Recent data is showing psychedelics can be real mega blockbuster Neuro drugs. Johns Hopkins recent trial on Psilocybin for smoking cessation showed an 80% success rate in terminating nicotine addiction, more than double any known therapeutic approach, including nicotine replacement therapy. This is showing addiction can be treated with new mechanisms that are much more low level than replacing the drug in the receptor. Academic data unequivocally shows that Ibogaine is 95% successful in terminating acute opioid withdrawal symptoms permanently from a single dosage. Limited data from long-term Ibogaine for opioid addiction trials show 50% success rates in terminating addiction in the 6 month period with a single dosage, more than 10X higher than the generous 5% success rate of other approaches in the 6 month period. Data from leading Ibogaine providers like Universal Ibogaine show that this 50% figure can be pushed closer to 75% with proper protocols and aftercare. Clinical trials on Psilocybin for cocaine/crack addiction are ongoing at the University of Alabama at Birmingham, a top 20 medical research university. 10 patients were un-blinded for bioethics review and the unpublished data shows that 30% never touched crack again while the other 70% had a relapse or two and turned their lives around, showing a 100% success rate in changing lives with minimal cost. When this data is available publicly in the next years, tidal waves of interest will move into the field.
Highlight:
Psychedelic Clinical Research Timeline
Projections:
As a recreational market, 0.1% of the population was surveyed as using psychedelics in the last month, placing the current black market at $19.1B while as a comparable percentage of the legal cannabis market adjusted for prevalence would place it at $8B.
As a medical market, the $373B neurogenics market seems to be the addressable market. Penetration into any indication in the neurogenics market would reap vast rewards. Psilocybin is on track to compete in the depression market with two FDA breakthrough designations, a 2% penetration into the depression market would being $1.4B+ in value yearly. Ibogaine's very reasonable projected 5% penetration into the opioid dependence market in the next 10 years will bring $9.6B+ in value yearly to groups like Universal Ibogaine which are deploying clinical infrastructure, supporting clinical trials and controlling the Ibogaine supply chain. Of all of the indications in current psychedelic clinical trials, not considering crossover, they address a $400B+ market, with projected penetrations across each indication and adjustments for market factors, it is projected $16B+ of value yearly will be created from commercialisation of the current late stage clinical trials which are in progress.
Highlight:
Johns Hopkins Psilocybin for Smoking Cessation Data
Challenges:
Regulatory Challenges:
While nearly 100 cities are creating legislation to decriminalize psychedelics and multiple US jurisdictions have passed decriminalization, federal changes will be required to open legal markets to the full potential. While investing in the binary risk of regulatory changes is standard in the junior markets, current regulatory controls are preventing early revenues. Many Canadian companies building production and distribution infrastructure offshore in jurisdictions such as Jamaica are operating in a legal grey area. While it is legal in Jamaica, any benefit or advantage given to a Canadian company could be considered a proceed of crime including IP development, capital repatriation and validation of technology offshore. Section 56 exemptions from Health Canada are required for Canadian companies working with psychedelics offshore and companies which are raising investment dollars without a secured Section 56 exemption may be incurring legal risk.
Cardiac Liability:
The unspoken elephant in the room of psychedelic derived pharmaceutical acceptance is not regulation, for example Ketamine is a scheduled drug which was recently approved for the general market. The problem is actually the liability of bringing a seratonergic based drug to the market like Psilocybin, DMT and LSD. The crippling withdrawal of blockbuster drug Fen-Phen and issues with other drugs like Imitrex due to seratonin agonist effects on the heart have scared the FDA into a position that any seratonergic drug will require extreme cooperation and diligence and will absolutely incur additional clinical and monitoring costs over other drugs. Psilocybin while technically hitting the 5ht2b receptor which causes cardiac side effects, does not have a high enough affinity to be a deal-breaker, meanwhile LSD having a very high affinity will cause large barriers for groups attempting to bring microdosed LSD to the market. Ibogaine suffers from cardiac liability due to an entirely different mechanism and unlike Psilocybin or LSD, adverse events have been reported. While Methadone and other standards of care also have the same long-QT cardiac liability at much higher rates and significantly higher mortality rates , Ibogaine clinical models must pre-screen patients for existing heart defects before procedures to guarantee no adverse side effects.
Banking/Insurance/Exchange Issues:
Legitimate psychedelic derived drug development companies have already had bank accounts halted at multiple banks for involvement in this industry and moving forward similar challenges faced by the cannabis industry should be expected. Exchanges and public offerings will have logistic challenges with this industry and minor friction has already been seen in the listing process. DNO insurance and other underwriting will be required to list in large markets and to date no psychedelic company has been underwritten, although underwriters and leading insurance brokers are actively exploring his industry.
Reimbursement:
The real whale will be insurance and single payer reimbursement of psychedelic derived pharmaceuticals on the market, allowing for global market uptake. Health systems have traditionally been decades behind the state of the art as seen in the point of care and home diagnostic device market, a market which could keep people healthy at minimal cost but has been crippled by lack of reimbursement.
Supply Chain Commoditization:
The production and control of psychedelic supply chains which is the familiar play of the cannabis industry will be a race to the bottom with magic mushrooms and other psychedelics. Production models are competing with a much more fluid black market and are being cannibalized by low cost home production and wildcrafting of psilocybin mushrooms. The LSD or ergoloid supply chain is highly monopolized, with the majority of the worlds ergoloids being produced in a single location. Companies competing in the production and supply chain space will face heavy price pressure and a highly coupled global regulatory system. The single outlier is Ibogaine, with a current global use estimated around 90kg, expected to reach 280kg in the next few years, this is a commodity whose price will drive through the roof. Large ibogaine producers have stopped production and natural sources are not commercially viable, with an Iboga plant producing maybe a single dose on the 10 year period, the move of Ibogaine to endangered status in 2019 and no synthetic GMP producers - the Ibogaine market is legal in the majority of the world and exploding while highly underserved and fragmented.
Delivery System Challenges:
A number of recent psychedelic deals are built around new drug delivery systems for psychedelics entering the recreational market to build expertise and infrastructure ready to move into the pharmaceutical market. Many of these technological approaches will not translate from the recreational market to the pharmaceutical market such as CBD/psychedelic compositions, natural product compositions as well as vaporizer and inhaler based delivery systems. While 20%+ of all new FDA drug entities are derived from natural products, natural product mixtures containing many products and a controlled substance have never and will never be FDA approved due to the regulatory system. Companies developing Psilocybin/CBD combinations and related therapeutics for the recreational market should understand that unlike the cannabis market, recreational approaches will not translate directly to medical approaches.
Opportunities:
Syndicated Investments:
One of the largest opportunities in any emerging market is syndicated investment, a 2002 analysis of 584 venture backed exits showed that syndicated investments produced double the rate of return of non-syndicated investments. Psychedelic research and development companies require standardized infrastructure that can be leveraged across a number of players. The big players entering the industry are more interested in empire building, requiring massive consolidations of commercial efforts which can be facilitated by syndicated investment groups. Companies like ThinkMyco, Entheogen Biosciences and Cybin Corporation which focus on technology development, IP Portfolios and early stage drug discovery will benefit the most from syndicated investment and collaboration. A Harvard Business School review of Pharma discovery programs statistically compared drug discovery programs to weapons research programs and found in these high reward/low incremental cost programs the optimal path is to run parallel programs, with an average Pharma drug discovery program having 16 parallel programs, 10 core and 6 low budget/high risk. At the current moment, around 5-10 psychedelic investment funds are forming in the range of $10-50M each, including the Cannacord Genuity backed Entheos and the $20M psychedelic quant fund Tabula Rasa Ventures.
IP Portfolio Development:
IP development is the highest value for dollar on the investment value chain and the psychedelic industry will be a totally IP driven industry. The most valuable patent portfolios will include new psychedelic compositions and therapeutic mechanisms, which require significant investments into fundamental R+D, while less competitive portfolios will include delivery system/psychedelic combinations.A recent review of patents related to psychedelics shows many hundreds of patents for psychedelic derived therapeutics with only a small cross-section being commercially competitive. DemeRX, the $40M+ Ibogaine research company holds 65+ patents in the ibogaine therapeutic area. While DemeRX filed for bankruptcy and their research and development assets were liquidated, it is rumored they have been injected with enough capital to come back to the party - this is a dark horse to keep an eye out for.
Mushroom/Protein Connection:
The real opportunity in magic mushroom production models is flying under the radar: protein production. Mushrooms are one of the highest quality sources of nutrition and protein, if you took a vitamin C supplement you can live exclusively off mushrooms. Dried mushrooms have basically the same protein percentage as beef and in terms of grams of protein per acre per year are 100 fold higher producers and much more sustainable than traditional agricultural practices. Companies in this space which invest into real R+D for lower cost mushroom production will get a lift from the $1.8+ trillion dollar protein market. A recent review of mid-sized mushroom farms shows that 50%+ of the cost of mushroom production is due to labor and technical inefficiencies. If energy, labor and materials cost drivers can be reduced, and the cost of growing a pound of mushrooms can drop from around $2 to around $0.75 through automation, mushroom protein becomes significantly more commercially competitive than many of the industry leaders in plant based protein like pea protein. If energy cost reductions can drop the cost even further, mushrooms will become a disruptive food source. Psychedelic companies building mushroom production infrastructure will be well served to remember that by investing in automation, new technology and new growing systems the price of mushroom based protein production can make it more competitive than any other food source. The largest food security report in history was released Q2 2019 and showed that without subsidies a hamburger would cost more than 30$ and the meat industry will economically collapse by 2040, the protein game is looking more and more attractive as a hedge against the regulatory risk of magic mushroom production.
China:
China is one of the most advanced markets in terms of size and pharma spending, as well as venture investment. Traditionally the Asian cultures had no interest in marginalized and politically tense areas such as drug medicalization but the movement into CBD and China's rabid interest in plant medicines may create a large influx of Asian capital moving into psychedelics. This industry shifting action will be leveraged by education and the court of public opinion. A dialog must be created showing psilocybin as a plant medicine and not a drug of abuse. Interestingly enough, Chinese firms have very recently started producing magic mushrooms industrially and importing them into the Canadian market where they are sold into the black market over-the-counter in some Canadian herbalist stores.
Ibogaine:
Ibogaine is the only psychedelic model which will not be very quickly commoditized. Ibogaine as a solution to the opioid problem is a disruptive technology, with the rise of fentanyl and fentanyl analogs like carfentanil dominating global supply chains, Buprenorphine, the preferred standard of care is no longer effective and produces a life threatening condition called Precipitated Withdrawal. This is due to the aggressive affinity of fentanyl to receptors, the lack of tolerance ceiling and the little understood metabolism of next-generation fentanyl analogues, dramatically compounding a problem already at pandemic levels. Ibogaine supply chains have collapsed at the same time that demand is growing exponentially, the firm which dominates the current global ibogaine supply chain will reap around $1.4M/mo profit serving the current global demand. One of the largest African Ibogaine brokers has seen a 30x increase in sales from 2017 to 2019. With Universal Ibogaine taking Ibogaine through the Canadian clinical process and the grassroots support from Health Canada, Ibogaine will be the first psychedelic approach available to consumers. While Ibogaine is a scheduled drug in the US and some European jurisdictions, it is not scheduled in Canada and the majority of the global market. Multiple Ibogaine documentaries are in filming, including actors such as Johnny Depp, as this is an education driven industry, we should expect exponential growth to accelerate in 2020.
Support Industries:
Industries supporting the growth of psychedelics will be a large part of the future landscape as was seen in the cannabis sector. A psychedelic business support network including education, conferences, business analysis and financing have already cropped up commercially. In Q3 2019 the renowned Cambridge House International Extraordinary Future conference created a panel for psychedelic opportunities. Two weeks before the conference there was a frantic rush and the majority of relevant psychedelic players were represented last minute in the panel discussion including: Compass Pathways, FieldTrip Ventures, Mind Medicine, Johns Hopkins, Dennis McKenna and ThinkMyco. Multiple psychedelic investment funds are forming alongside of industry press, consulting groups and other support interests. In Q3 2019, Dr. Matthew Thompson of Johns Hopkins and Dr. Charles Nichols of LSU/Eleusis Benefit Corporation helped organize the inaugural conference for the new journal called International Society for Research on Psychedelics in its home of New Orleans. Over 100 international scientists from top universities were represented, with the conference having to turn down many late registrations. Dr. Rolland Griffiths, head of the Johns Hopkins Psychedelic Research Center said "This was the best scientific conference I have been to in my entire career.".
Sub-perceptual dosing:
Microdosing was popularized by Silicon Valley, catalyzing the resurgence of the psychedelic industry but microdosing is a protocol built on unsound fundamentals. Research shows that the therapeutic effects of psychedelics are highly dose dependant, higher doses lead to better therapeutic effects. The microdosing supply chain model has excellent returns, with a pound of mushrooms costing less than 5$/lb to produce which provides around 1200X microdoses. When dosages increase past the perceptual threshold, the potential for adverse events such as bad trips exponentially increases. The ideal dosage seems to be just under perceptual threshold where you can still go about your day, but much higher than a microdose. This is industry standard with seratonergic pharmaceuticals, an example being the diet drug Belvique, which is closely related to psilocybin, dosed at the perceptual threshold for maximum effectiveness. Belvique can cause psilocybin like hallucinations if 4 tablets are taken as it is a seratonergic drug. High doses of psilocybin require a clinical infrastructure and in-patient experience, dramatically increasing costs and logistics overheads. Sub-perceptual dosed pharmaceuticals will be available for out-patient and take home treatment and in many cases may be as effective as full blown psychedelic experiences. Mind Medicine, ThinkMyco and Eleusis Benefit Corporation are leading the charge in sub-perceptual therapeutics.
Next Generation Drug Development:
Mind Medicine is taking the approach of engineering the hallucinations out of the therapeutic experience by removing parts of the molecule and are moving their drug, 18-MC through the clinical process. This is the ultimate high risk/high reward play in the psychedelic industry. 18-MC is modified which also changes a variety of important receptor binding effects. The modified receptors include the receptors responsible for neural growth factor release, cognitive effects, cardiac effects and the opioid system coupled NMDA receptor system. Since there is no data on the human use of 18-MC in opioid addicts, significant capital must be deployed before it is even known if 18-MC is as efficient as the parent molecule Ibogaine for treating opioid addiction, the ability to treat addiction in an out-patient setting with no cardiac toxicity - 18-MC will be the megablockbuster all investors in the neurogenic space are waiting for. ThinkMyco, Gilgamesh Pharmaceuticals, Mind Medicine and Eleusis Benefit Corporation are leading the field in next generation drug development.
Lateral Drug Development:
While psychedelics address a $373B neurogenics market, companies such as Eleusis Benefit Corporation are showing they can address other unmet clinical needs such as chronic inflammatory disease. Eleusis is developing new psychedelic compounds for the treatment of inflammation, specifically within ophthalmology, and has recently published Phase I trial results revealing the safety and tolerability of low dose LSD in healthy older adults, with the intention of evaluating low dose LSD as a disease modifying therapy in Alzheimer's disease. Eleusis Benefit Corporation looks poised to cannibalize the $3B steroid therapeutic market. Not yet published research is showing Ibogaines potential as a therapeutic to treat sleep disorders. Johns Hopkins is currently reviewing the application of psychedelics in pulling patients from comas and vegetative states. The original pre-Mind Medicine clinical trials on the Ibogaine derivative 18-MC showed promise in treating Leishmania infection. BOL148, an inactive form of LSD, originally the placebo in human clinical LSD research, was found to in some cases to permanently terminate cluster headaches after a few doses and is being publicly demanded from the cluster headache community. These are the earliest days of understanding the application of psychedelic derived chemistry as new therapeutic approaches.
Public Health Engagement:
Looking at recently released data representing North American, working class adults, methamphetamine and fentanyl use is growing enormously and consistently. Linear regression of growth rates over the last 5 years projects a 380%+ increase in Fentanyl usage the next 15 years, with Methamphetamine projected at a 475%+ increase. This is concerning as there are more than a million high quality data points over 5 years and an R2 value of 90%+ which paints of picture of statistical certainty. This shows that the opioid crisis has moved from a lift caused by supply side drivers to an organically growing demand side driven pandemic, fueled secondarily by histories cheapest and most available synthetic drugs. With Johnson and Johnson settling with two counties in Ohio, projections have placed the total at $100B+ in fines for the opioid crisis in the next few years. State jurisdictions will shortly receive an enormous amount of cash that will be legally obligated to flow into anti-addiction spending. Due to poor outcomes and non-scalable approaches around advanced public health programs, there will be a flurry of legislature to address how to spend the $100B+ anti-addiction warchest. Players like Universal Ibogaine who have proven clinical models, can deploy infrastructure and guarantee statistically better outcomes will receive unprecedented amounts of non-dilutive government funding and will be the first to benefit from Decriminalization/Medicalization in the North American market. Players that can come to the table now at the state level and propose medicalization legislature as well as profitable clinical infrastructure with proven outcomes, could monopolize the entire US market. FieldTrip Ventures is developing Psilocybin clinical infrastructure while Universal Ibogaine is deploying proven clinical infrastructure already developed and proven by Clear Sky Recovery, the leading Ibogaine clinical experts with thousands of successful detox procedures and no critical adverse events.
Closing:
Like any emerging industry, there are challenges and growing pains but the blue-sky upside is unparalleled. "Black swan events are characterised by their extreme rarity, their severe impact, and the practice of explaining widespread failure to predict them as simple folly in hindsight." Due to changes in public opinion, a mental health and addiction pandemic as well as enormous movements of liquid cash, this sector is poised to explode in 2020.
submitted by mindovermatterlondon to investing [link] [comments]

For the last two years I’ve been writing down new business ideas everyday, I've written a free book featuring 101 of the best ideas, here's the first 50 ideas.

Hello everyone,
Craig here, fellow internet entrepreneur.
For the last two years I’ve been writing down new business ideas everyday.
I’ve filled many notepads with 1000’s of ideas.
Weird ideas, bad ideas, fun ideas and great ideas.
I’ve painstakingly gone through all of my notepads and picked the 101 best new business ideas.
Below I’ve listed 50 from my free ebook which is available here.
Feel free to use these ideas and make something of them : )
Enjoy!
Laundry Locker
Set up a laundry service that washes your dirty clothes at the gym. Leave your dirty clothes in your gym locker. The service picks them up, washes them and puts them back in your locker. The business model could be a monthly subscription or per load basis.
Coffee Run
Create an app where you can order coffee straight to your desk at work. The app would summon coffee runners in your office building to purchase and deliver hot coffee to your desk from local coffee shops. The coffee runners would get paid a delivery fee, the app would make a percentage on every sale.
Off Peak Office
Create a website where you can book and use office space in off peak times from 6pm to 9am when the offices aren’t being used. Charge a commission on top of every off peak office booking.
A.R. Personal Trainer
Create an app that uses augmented reality to create your very own virtual personal trainer. At the gym, your A.R. personal trainer will show you how to use the gym equipment and take you through exercise routines. The business model would be a monthly subscription or a one-off fee for the app.
The World's Best
Create a website that sells only the world's best products. From cars to watches to vacuum cleaners. Sell only the very best of every product ever made. The business model would involve direct sales or earn affiliate commissions.
Money Can’t Buy
Create a website that sells money can’t buy experiences. The site would feature experiences that are extremely rare and expensive. For example, you could sell the opportunity to join a ring walk at a world championship boxing match. Or get a one-on-one meeting with Richard Branson. The business model would be to make a commission on top of the sale of the experiences.
Celebrity Morning Routines
Create a website that features morning routines of your favourite celebrities, including sports stars, film and television stars and business moguls. The site would feature celebrities taking you through their morning routines via video. The business model would involve charging a monthly fee to access the site.
Moving Media
Create a global media empire by selling advertising space on the side of trucks and vans. 1000’s of truck trailers are on the road each day. These spaces could be turned into huge billboards. Ad spaces would be booked and paid online. You could also charge for producing the ad creative.
Speaker Spaces
Create an online marketplace that allows you to find and book venues exclusively for speaking engagements. The site would list all the details of the speaker spaces including capacity, equipment etc. Money would be from a booking fee added to the venue hire.
Retro Arcade Centre
Open an old school arcade venue that features only retro, coin-operated arcade machines from the ’80s and early ’90s. You could charge an hourly fee for access, or let people pump money into the machines.
Office Product Placement
Create a company that sells product placement within companies. For example, you could charge to create and place branded coffee mugs within an office space. Another example would be branded stationery. Brands would pay your company to create branded products and also pay a fee to have them placed within their chosen office environment.
The Commute Channel
Create entertainment that is the length of people’s commute. The content would sit within an app where people enter their commute time. They would be presented with a range of podcasts, videos or short reads to consume that are the length of their travel. The business model would be an advertising model or pay a monthly subscription.
Bike Valet
Create a valet service for bikes. Ride your bike to the front of your workplace, valet staff would grab your bike and lock it up somewhere secure while you’re at work. When you want to leave, summon the valet via an app. They bring your bike back to you ready to go. Valet staff could also service your bike for an additional fee. Riders would pay a monthly subscription or per valet fee.
Package Concierge
A service in large apartment blocks that accepts packages on your behalf. Get your package delivered to a concierge who would hold your package and deliver it to you when you want. The business model could be a monthly subscription or per package. The package holders would also receive a fee for holding and delivering packages.
Casual Uniform Store
A clothing store that sells casual uniforms. For example, you buy 5 sets of casual work clothes. Your casual uniform is exactly the same for each day. You just have a new set for each day. The casual uniforms would be chosen for you by a top stylist. The business model would be to charge people for a personal stylist and get a discount for buying 5 sets of exactly the same casual uniform.
Urban Armour
Create a range of designer bulletproof and stab-resistant streetwear. Create casual looking jackets, jeans and even underwear. Sell the range online or open a street store.
Directors Cut Films
Create a website that streams only uncut or directors cut versions of films. Most films broadcast on streaming services have been cut down from the original to comply with regulations. The business model could be a monthly subscription or a fee for each film downloaded.
Anti Snoop Smart Phone Covers
Create and sell mobile phone covers and lenses that stop people from snooping on your mobile phone screen whilst in public. Your screen could be viewed only by looking at it directly, and not from an angle to keep people out.
Apartment Finder
Create a service that finds, views and organises you a new apartment or room rental. The apartment finder find would take the hassle out of the whole process. You could create an app that allows the apartment finder to present you with options for your approval. The apartment finder could even do your paperwork and move your stuff in.
Luggage Lugger
A service that picks up your luggage and takes it to the airport for you. The service would pick up your luggage at a designated time, transporting it out to the airport storing it securely for you. This service would be great for large families and less mobile people. The service would have to be much cheaper than a taxi to be cost-effective. Business model would be a one-off fee based on weight and distance.
Ready Hotel Rooms
A hotel room that features a whole wardrobe and range of products ready for you to wear and use. The ready hotel room would eliminate the need to pack and take a suitcase on your trip. Clothes and products would be preselected based on your existing wardrobe and home. Business model would be a premium fee placed on top of the hotel room fee.
Winter Wardrobe
Create a service that picks up, packs and stores your winter wardrobe over summer. The business model would be based on the volume and length of time stored. The clothes could also be dry cleaned whilst in storage.
Sponsored Book Covers
A unique way to create awareness of new books would be to create and distribute book cover sleeves. People could be paid to wrap the sponsored book cover over their book. This would be for people in high exposure areas like public transport. Business model would be charge people to create and distribute their book covers to people. People using the covers would be paid a small fee or given book discounts.
Do Not Disturb Me Chairs
Create chairs for people who work in open plan offices that have a do not disturb sign built into them. Users could flip the sign on when they want to focus and not be disturbed by co-workers. Special chairs would have to be manufactured or you could create and sell signs that fit onto chairs.
Personal Motivation Service
Create a service where a person would call you and send texts to motivate you. For example, they would motivate you to go to the gym, finish a project or get some study done. The business model would be a monthly subscription.
Lifetime Jeans
Create a jeans brand that will collect, repair and deliver your jeans back to you when they wear out. Especially good for those holes you always get in the crotch. The business model is simply selling jeans with a lifetime warranty.
Dog-Friendly Places
Create a site that allows dog owners to find dog-friendly restaurants, pubs and places anywhere in the world. The business model could be charging people a small fee to list their business. Or selling advertising space on the site.
On-Site Bike Servicing
Create a service that will send people out to fix your bike wherever you are. You could create an app that summons the service with a push of a button that would get to your location in minutes. The business model would be a monthly subscription.
Pet Air
Create an airline that only flies pets and their owners. Seating within the aircraft would be specially designed with pets in mind. To keep things civilised there would be a 50 / 50 ratio of people to pets.
New Employee Welcome Packs
Create a company that provides custom welcome packs for new employees at large companies. Like hampers but for new employees. The business model would be on a per pack basis which would be created and delivered on demand.
Last Minute Movies
Create an app that allows you to buy last-minute movie tickets at empty theatres. Because the movie theatres are empty at the last minute, the tickets would be cheaper to buy. The business model would be a small commission on the sale of each movie ticket you sell.
Celebrity Store
Create an e-commerce store that only lists products used and endorsed by celebrities and successful business people. The business model could be direct purchase or affiliate commissions.
Safest Neighbourhoods
Create a data-backed website that lists the safest areas to live in each city. The data would be supplied by the police or government. The business model would be a monthly membership for people or charge real estate agents to access the data.
Analogue Restaurants and Bars
Set up a chain of bars and restaurants that don’t allow any form of digital device. There is no wifi. The business model would encourage social interaction. The money would be made the normal way from selling food and drinks.
Life, Automated
Set up a website that features only products that automate every aspect of your life. From vacuum cleaners to automated pet feeders. Sell products directly or make money from affiliate sales.
Weather Fashion
Set up a social media account or a website that has weather forecasts matched with fashion that is applicable to the temperature. For example, if it’s going to be just 10 degrees on Tuesday, have a picture of a fashion model wearing warm designer clothes. The business model could be paid sponsorships, or sell clothes directly.
Haggle School
Create a service that teaches people how to haggle better with advanced haggling techniques. Classes would be taught online or in person. A fee would be charged for the classes.
Cracked Phone Concierge
Mobile phone repair that comes to you. Book and pay for your repair online, the technician comes to your home or workplace and repairs your phone on the spot.
Podcast Ad Network
Set up a media agency that sells ad space on podcasts. Ad production could also be done by the company. The business model is creating and selling ad space on podcasts.
Food Medicine Store
Set up an online store or real-life store that sells products based on what illness you may have. For example, I have a cold. Okay, we recommend these products x, y and z.
The Lifebrary
Set up a bookstore or book recommendation site lists the best books to read when you’re at a certain point in your life. For example, the best books to read when starting a new business. Best books to read when you’re pregnant. Sell books directly or make a commission from affiliates.
Training Buddy
Create an app or that allows you to find people to train within your local gym. Arrange time and place via an app. The business model could be a monthly subscription.
A.R. Tour Guides
Create an app that allows you to view augmented reality tour guides in your city. Guides would be on every corner telling you about the area. View and listen to the guides via your mobile phone. Business model selling the app in the app store for a one time fee.
Flatemately
Set up a monthly subscription business that supplies common household goods to share houses. For example, toilet paper, garbage bags and cleaning products. Payment for the service could be split between housemates. The subscription-only comes when each housemate has paid their fee.
Blue Zone Food Store
A shop that sells only Blue Zone foods. A Blue Zone is a part of the world where people are most healthy and live the longest. A study found these people eat certain types of food, therefore, they live long, healthy lives. Blue Zone recipes and food kits could also be sold.
Where I’ve Been
Create a website that allows people to plot on a map where they’ve visited in the world. People could download and or print a poster of where they’ve been. The business model would be selling printed posters of world maps and where they’ve been. You could also monetise the site by offering advertising to travel companies.
Dating Profile Optimization
Create a service that will optimize people’s online dating profiles for maximum conversions. The service would offer professional profile writing done by the opposite sex and also professional profile photo photography packages.
Hot People Only Dating App
Create an app that only allows people of certain attractiveness to join. New members would be vetted for attractiveness. The business model could be a premium monthly subscription like other dating apps.
Modern Speed Dating
Create an app that organises traditional speed dating. Use the app to view other speed daters, and also book and pay for speed dating sessions. The business model could be a per session fee or a monthly subscription.
Quiet Neighbourhood Finder
Create a database that allows you to find the quietest neighbourhood in your city. The site would feature historical noise pollution data and noise pollution complaints data over time. A business model could be charging for a monthly membership, or data could be sold to real estate agents.
submitted by craigbarber to Entrepreneur [link] [comments]

2020 Psychedelic Industry Insights Report - ThinkMyco

2020 Psychedelic Industry Insights Report
By: Nikita Alexandrov BChem, MBA - CTO, ThinkMyco
[email protected]
Jan 8th, 2020
2019 was a pivotal year in the psychedelic industry with US decriminalization actions, two companies receiving FDA breakthrough status for psilocybin, funding of the $16M Johns Hopkins Psychedelic Research Center, The US Defence Department starting their rumored $20M+ Focused Pharma psychedelic science program and the movement of top universities into research and clinical trials. With the explosion of the more than $100M dollars worth of investable psychedelic opportunities in Q3 2019, the collapse of high quality cannabis investments, one of the best decembers on record and a potential $1B scale psychedelic IPO - 2020 will be the year of psychedelic investment.
The movement in the field recently is just a blip compared to what is to come, this industry has been brewing for the last few decades. Big Pharma has failed when it comes to new approaches to brain and central nervous system treatment. Neuro drugs have half the success rate of all Pharma projects, which caused most of the big players to liquidate their neuro programs in the last decade. Recently, engagement is exploding with new clinical legislature supporting neuro, the recent approval of 3 potentially blockbuster neuro drugs in the last 2 years, Q2 2019 saw a record of over $320M in investment into neuro drug development. Interestingly enough an influential group of ultra-high net worth individuals to funded the psychedelic holding company Atai Lifesciences which went on to fund Compass Pathways and continues to fund commercial efforts in this field. Atai Lifesciences recent movements are a familiar story of acquisition and consolidation in an emerging market which will be a common theme in the future of the psychedelic industry. The collapse of investable cannabis opportunities are driving investors comfortable in stigmatized industries and binary risk to the table with big pharma, cutting edge science and huge unmet market needs to create a perfect storm of opportunity.
Highlight:
Investors seek 'mega blockbuster' drugs as neuroscience undergoes renaissance
How big is the Psychedelic Industry?
Historically, the psychedelic industry has been fragmented with around $60M worth of companies in the last 20 years, many of which were not sustainable. The current industry is around $300M worth of investments, dominated by the Peter Thiel backed Atia Lifesciences at $100M+ and Compass Pathways at $50M+, followed by Mind Medicine at $10M+, Fieldtrip Ventures at $10M+ and then a 10-15 early companies in the range of $2.5-10M each. The $300M worth of investable deals have only existed since the public formation of Compass Pathways in 2016, with the majority leaving stealth mode in 2019.
Highlight:
Transforming psychedelics into mainstream medicines
How big is the Psychedelic Market?
The psychedelic market is emerging while highly coupled to clinical/regulatory events and is split between recreational and medical psychedelic markets:
Recreational: $8-19.2B
Calculated from cannabis market and comparable usage prevalence as well as demand size economics.
Medical: $373B
Calculated from the main markets addressable by psychedelic therapeutics (neurogenics market): mental health drugs, therapy spending, neurodegeneration drugs and cognitive enhancement.
Highlight: Analysis of the Psilocybin Pharmaceutical Market
Who are the players?
Atai Lifesciences - German based, Global psychedelic pharma holding company formed by ultra-high net worth individuals and big pharma, $150M+
Compass Pathways - London based psychedelic giant, Atai's bet on psilocybin as an approved drug for depression, $50M+, IPO 2020
Usona Institute - A Wisconsin based non-profit powerhouse competing with Compass Pathways to approve psilocybin for depression.
Mind Medicine - Toronto based ibogaine derived addiction drug development company taking their lead candidate 18-MC through the clinical approval process, raising $15M, RTO in 2020
Eleusis Benefit Corporation - New Orleans based discovery/clinical stage Psychedelic pharma company supported by industry scientists, raising $25M
FieldTrip Ventures - Toronto based, Aurora backed magic mushroom research and development company building clinical and production infrastructure, raising $10M+
ThinkMyco - Vancouver based holding company developing disruptive mushroom production technology and next generation therapeutics, raising $5M+
Gilgamesh - Psychedelic drug discovery company affiliated with the Atai owned Perception Neuroscience and Columbia University, raising 10M+
Universal Ibogaine - Vancouver based Ibogaine clinical development company franchising the world's most advanced ibogaine clinical model, raising $10M+, RTO in 2020
PsyGen - Alberta based psychedelic mass production and clinical research company with highly experienced production chemists $5M+
Entheogen Biosciences - Vancouver based company pursuing psilocybin and DMT based drug development, raising $3M, IPO in 2020
Salvation Botanicals - A Vancouver based company touting a private controlled substances site license and supporting clinical research, raising $10M+, RTO in 2020 Numinus Wellness - Vancouver based wellness company building testing as well as clinical infrastructure, partnered with Salvation, raising $5M+, RTO in 2020
Cybin Corp - Toronto based research and development company building drug development and production infrastructure as well as nutraceutical assets in legal jurisdictions, raising $3M
Emerging Players - There are a number of emerging players, around $25M+ in emerging deals in Q3 2019 which have not passed due diligence.

Clinical:
Recent data is showing psychedelics can be real mega blockbuster neuro drugs. Johns Hopkins recent trial on Psilocybin for smoking cessation showed an 80% success rate in terminating nicotine addiction, more than double any known therapeutic approach, including nicotine replacement therapy. Academic data shows that Ibogaine is 95% successful in terminating acute opioid withdrawal/addiction. Limited data from Ibogaine for opioid addiction trials show 50% success rates in terminating addiction, more than 10X higher than the generous 5% success rate of other approaches. Data from leading Ibogaine providers like Universal Ibogaine show that this 50% figure can be pushed closer to 75% with proper protocols and aftercare. Clinical trials on Psilocybin for cocaine/crack addiction are ongoing at the University of Alabama at Birmingham, a top 20 medical research university. 10 patients were un-blinded for bioethics review and the unpublished data shows that 30% never touched cocaine again while the other 70% had a relapse or two and turned their lives around, showing a 100% success rate in changing lives with minimal cost. When this data is available publicly in the next years, tidal waves of interest will move into the field.
Highlight:
Psychedelic Clinical Research Timeline
Projections:
As a recreational market, 0.1% of the population was surveyed as using psychedelics in the last month, placing the current black market at $19.1B while as a comparable percentage of the legal cannabis market adjusted for prevalence would place it at $8B.
As a medical market, the $373B neurogenics market seems to be the addressable market. Penetration into any indication in the neurogenics market would reap vast rewards, Psilocybin is on track to compete in the depression market with two FDA breakthrough designations, a 2% penetration into the depression market would being $1.4B in value. Ibogaines very reasonable projected 4% penetration into the opioid dependence market will bring $9.6B in value yearly to groups like Universal Ibogaine which are deploying clinical infrastructure, supporting clinical trials and controlling the Ibogaine supply chain. Of all of the indications in current psychedelic clinical trials, not considering crossover, they address a $400B+ market, with projected penetrations across each indication and adjustments for market factors, it is projected $16B+ of value yearly will be created from commercialization of current late stage clinical trials.
Highlight: Johns Hopkins Psilocybin for Smoking Cessation Data
Challenges:
Regulatory Challenges:
While nearly 100 cities are creating legislation to decriminalize psychedelics and multiple US jurisdictions have passed decriminalization, federal changes will be required to open legal markets to the full potential. While investing in the binary risk of regulatory changes is standard in the junior markets, current regulatory controls are preventing early revenues. Many Canadian companies building production and distribution infrastructure offshore in jurisdictions such as Jamaica are operating in a legal grey area. While it is legal in Jamaica, any benefit or advantage given to a Canadian company could be considered a proceed of crime including IP development, capital repatriation and validation of technology offshore. Section 56 exemptions from Health Canada are required for Canadian companies working with psychedelics offshore and companies which are raising investment dollars without a secured Section 56 exemption may be incurring legal risk.
Cardiac Liability:
The unspoken elephant in the room of psychedelic derived pharmaceutical acceptance is not regulation, for example Ketamine is a scheduled drug which was recently approved. The problem is actually the liability of bringing a seratonergic based drug to the market like Psilocybin, DMT and LSD. The crippling withdrawal of blockbuster drugs Fen-Phen and issues with other drugs like Imitrex due to seratonin agonist effects on the heart have scared the FDA into a position that any seratonergic drug will require extreme cooperation and diligence and will absolutely incur additional clinical and monitoring costs over other drugs. Psilocybin while technically hitting the 5ht2b receptor which causes cardiac side effects, does not have a high enough affinity to be a deal-breaker, meanwhile LSD having a very high affinity will cause large barriers for groups attempting to bring microdosed LSD to the market. Ibogaine suffers from cardiac liability due to an entirely different mechanism and unlike Psilocybin or LSD, adverse events have been reported. While Methadone and other standards of care also have the same long-QT cardiac liability at much higher rates and significantly higher mortality rates , Ibogaine clinical models must pre-screen patients for existing heart defects before procedures to guarantee no adverse side effects.
Banking/Insurance/Exchange Issues:
Legitimate psychedelic derived drug development companies have already had bank accounts halted at multiple banks for involvement in this industry and moving forward similar challenges faced by the cannabis industry should be expected. Exchanges and public offerings will have logistic challenges with this industry and minor friction has already been seen in the listing process. DNO insurance and other underwriting will be required to list in large markets and to date no psychedelic company has been underwritten, although underwriters and leading insurance brokers are actively exploring his industry.
Reimbursement:
The real whale will be insurance and single payer reimbursement of psychedelic derived pharmaceuticals on the market, allowing for global market uptake. Health systems have traditionally been decades behind the state of the art as seen in the point of care and home diagnostic device market, a market which could keep people healthy at minimal cost but has been crippled by lack of reimbursement.
Supply Chain Commoditization:
The production and control of psychedelic supply chains which is the familiar play of the cannabis industry will be a race to the bottom with magic mushrooms and other psychedelics. Production models are competing with a much more fluid black market and are being cannibalized by low cost home production and wildcrafting of psilocybin mushrooms. The LSD or ergoloid supply chain is highly monopolized, with the majority of the worlds ergoloids being produced in a single location.
Companies competing in the production and supply chain space will face heavy price pressure and a highly coupled global regulatory system. The single outlier is Ibogaine, with a current global use estimated around 90kg, expected to reach 280kg in the next two years, this is a commodity whose price will drive through the roof. Large ibogaine producers have stopped production and natural sources are not commercially viable, with an Iboga plant producing maybe a single dose on the 10 year period, the move of ibogaine to endangered status in 2019 and no synthetic GMP producers - the ibogaine market is legal in the majority of the world and exploding while highly underserved and fragmented.
Delivery System Challenges:
A number of recent psychedelic deals are built around new drug delivery systems for psychedelics entering the recreational market to build expertise and infrastructure ready to move into the pharmaceutical market. Many of these technological approaches will not translate from the recreational market to the pharmaceutical market such as CBD/psychedelic compositions, natural product compositions as well as vaporizer and inhaler based delivery systems. While 20%+ of all new FDA drug entities are derived from natural products, natural product mixtures containing many products and a controlled substance have never and will never be FDA approved due to the regulatory system. Companies developing Psilocybin/CBD combinations and related therapeutics for the recreational market should understand that unlike the cannabis market, recreational approaches will not translate directly to medical approaches.
Opportunities:
Syndicated Investments:
One of the largest opportunities in any emerging market is syndicated investment, a 2002 analysis of 584 venture backed exits showed that syndicated investments produced double the rate of return of non-syndicated investments. Psychedelic research and development companies require standardized infrastructure that can be leveraged across a number of players. The big players entering the industry are more interested in empire building, requiring massive consolidations of commercial efforts which can be facilitated by syndicated investment groups. Companies like ThinkMyco, Entheogen Biosciences and Cybin Corporation which focus on technology development, IP Portfolios and early stage drug discovery will benefit the most from syndicated investment and collaboration. A Harvard Business School review of Pharma discovery programs statistically compared drug discovery programs to weapons research programs and found in these high reward/low incremental cost programs the optimal path is to run parallel programs, with an average Pharma drug discovery program having 16 parallel programs, 10 core and 6 low budget/high risk.
IP Portfolio Development:
IP development is the highest value for dollar on the investment value chain and the psychedelic industry will be a totally IP driven industry. The most valuable patent portfolios will include new psychedelic compositions and therapeutic mechanisms, which require significant investments into fundamental R+D, while less competitive portfolios will include delivery system/psychedelic combinations.
A recent review of patents related to psychedelics shows many hundreds of patents for psychedelic derived therapeutics with only a small cross-section being commercially competitive. DemeRX, the $40M+ Ibogaine research company holds 65+ patents in the ibogaine therapeutic area. While DemeRX filed for bankruptcy and their research and development assets were liquidated, it is rumored they have been injected with enough capital to come back to the party - this is a dark horse to keep an eye out for.
Mushroom/Protein Connection:
The real opportunity in magic mushroom production models is flying under the radar: protein production. Mushrooms are one of the highest quality sources of nutrition and protein, if you took a vitamin C supplement you can live exclusively off mushrooms. Dried mushrooms have basically the same protein percentage as beef and in terms of grams of protein per acre per year are 100 fold higher producers and much more sustainable than traditional agricultural practices. Companies in this space which invest into real R+D for lower cost mushroom production will get a lift from the $1.8 trillion dollar protein market. A recent review of mid-sized mushroom farms shows that 50%+ of the cost of mushroom production is due to labor and technical inefficiencies. If energy, labor and materials cost drivers can be reduced, and the cost of growing a pound of mushrooms can drop from around $2 to around $1.20 through automation, mushroom protein becomes significantly more competitive than many of the industry leaders in plant based protein like pea protein. If energy cost reductions can drop the cost even further, mushrooms will become a disruptive food source. Psychedelic companies building mushroom production infrastructure will be well served to remember that by investing in automation, new technology and new growing systems the price of mushroom based protein production can make it more competitive than any other food source. The largest food security report in history was released Q2 2019 and showed that without subsidies a hamburger would cost more than 30$ and the meat industry will economically collapse by 2040, the protein game is looking more and more attractive as a hedge against the regulatory risk of magic mushroom production.
China:
China is one of the most advanced markets in terms of size and pharma spending, as well as venture investment. Traditionally the Asian cultures had no interest in marginalized and politically tense areas such as drug medicalization but the movement into CBD and China's rabid interest in plant medicines may create a large influx of Asian capital moving into psychedelics. This industry shifting action will be leveraged by education and the court of public opinion. A dialog must be created showing psilocybin as a plant medicine and not a drug of abuse. Interestingly enough, Chinese firms have very recently started producing magic mushrooms industrially and importing them into the Canadian market where they are sold into the black market over-the-counter in some Canadian herbalist stores.
Ibogaine:
Ibogaine is the only psychedelic model which will not be very quickly commoditized. Ibogaine as a solution to the opioid problem is a disruptive technology, with the rise of fentanyl and fentanyl analogs like carfentanil dominating global supply chains, Buprenorphine, the preferred standard of care is no longer effective. This is due to the aggressive affinity of fentanyl to receptors, the lack of tolerance ceiling and the little understood metabolism of next-generation fentanyl analogues, dramatically compounding a problem already at pandemic levels. Ibogaine supply chains have collapsed at the same time that demand is growing exponentially, the firm which dominates the current global ibogaine supply chain will reap around $1.4M/mo profit serving the current global demand. One of the largest African Ibogaine brokers has seen a 30x increase in sales from 2017 to 2019. With Universal Ibogaine taking Ibogaine through the Canadian clinical process and the grassroots support from Health Canada, Ibogaine will be the first psychedelic approach available to consumers. While Ibogaine is a scheduled drug in the US and some European jurisdictions, it is not scheduled in Canada and the majority of the global market. Multiple Ibogaine documentaries are in filming, including actors such as Johnny Depp, as this is an education driven industry, we should expect exponential growth to accelerate in 2020.
Support Industries:
Industries supporting the growth of psychedelics will be a large part of the future landscape as was seen in the cannabis sector. A psychedelic business support network including education, conferences, business analysis and financing have already cropped up commercially. In Q3 2019 the renowned Cambridge House International Extraordinary Future conference created a panel for psychedelic opportunities. Two weeks before the conference there was a frantic rush and the majority of relevant psychedelic players were represented last minute in the panel discussion including: Compass Pathways, FieldTrip Ventures, Mind Medicine, Johns Hopkins, Dennis McKenna and ThinkMyco. Multiple psychedelic investment funds are forming alongside of industry press, consulting groups and other support interests. In Q3 2019, Dr. Matthew Thompson of Johns Hopkins and Dr. Charles Nichols of LSU/Eleusis Benefit Corporation helped organize the inaugural conference for the new journal called International Society for Research on Psychedelics in its home of New Orleans. Over 100 international scientists from top universities were represented, with the conference having to turn down many late registrations. Dr. Rolland Griffiths, head of the Johns Hopkins Psychedelic Research Center said "This was the best scientific conference I have been to in my entire career.".
Sub-perceptual dosing:
Microdosing was popularized by Silicon Valley, catalyzing the resurgence of the psychedelic industry but microdosing is a protocol built on unsound fundamentals. Research shows that the therapeutic effects of psychedelics are highly dose dependant, higher doses lead to better therapeutic effects. The microdosing supply chain model has excellent returns, with a pound of mushrooms costing less than 5$/lb to produce which provides around 1200x microdoses. When dosages increase past the perception threshold, the potential for adverse events such as bad trips exponentially increases. The ideal dosage seems to be just under perceptual threshold where you can still go about your day, but much higher than a microdose. This is industry standard with seratonergic pharmaceuticals, an example being the diet drug Belvique, which is closely related to psilocybin, dosed at the perceptual threshold for maximum effectiveness. Belvique can cause psilocybin like hallucinations if 4 tablets are taken as it is a seratonergic drug. High doses of psilocybin require a clinical infrastructure and in-patient experience, dramatically increasing costs and logistics overheads. Sub-perceptual dosed pharmaceuticals will be available for out-patient and take home treatment and in many cases may be as effective as full blown psychedelic experiences. Mind Medicine, ThinkMyco and Eleusis Benefit Corporation are leading the charge in sub-perceptual therapeutics.
Next Generation Drug Development:
Mind Medicine is taking the approach of engineering the hallucinations out of the therapeutic experience by removing parts of the molecule and are moving their drug, 18-MC through the clinical process. This is the ultimate high risk/high reward play in the psychedelic industry. 18-MC is modified which also changes a variety of important receptor binding effects. The modified receptors include the receptors responsible for growth factor release, cognitive effects, cardiac effects and the opioid system coupled NMDA receptors. Since there is no data on the human use of 18-MC in opioid addicts, significant capital must be deployed before it is even known if 18-MC is as efficient as the parent molecule Ibogaine for treating opioid addiction, the ability to treat addiction in an out-patient setting with no cardiac toxicity - 18-MC will be the megablockbuster all investors in the neurogenic space are waiting for. ThinkMyco, Gilgamesh, Mind Medicine and Eleusis Benefit Corporation are leading the field in next generation drug development.
Lateral Drug Development:
While psychedelics address a $373B neurogenics market, companies such as Eleusis Benefit Corporation are showing they can address other unmet clinical needs such as chronic inflammatory disease. Eleusis is developing new psychedelic compounds for the treatment of inflammation, specifically within ophthalmology, and has recently published Phase I trial results revealing the safety and tolerability of low dose LSD in healthy older adults, with the intention of evaluating low dose LSD as a disease modifying therapy in Alzheimer's disease. Eleusis Benefit Corporation looks poised to cannibalize the $3B steroid therapeutic market. Not yet published research is showing Ibogaines potential as a therapeutic to treat sleep disorders. Johns Hopkins is currently reviewing the application of psychedelics in pulling patients from comas and vegetative states. The original pre-Mind Medicine clinical trials on the Ibogaine derivative 18-MC showed promise in treating Leishmania infection. BOL148, an inactive form of LSD, originally the placebo in human clinical LSD research, was found to in some cases to permanently terminate cluster headaches after a few doses and is being publicly demanded from the cluster headache community. These are the earliest days of understanding the application of psychedelic derived chemistry as new therapeutic approaches.
Public Health Engagement:
Looking at recently released data representing North American, working class adults, methamphetamine and fentanyl use is growing enormously and consistently. Linear regression of growth rates over the last 5 years projects a 380%+ increase in Fentanyl usage the next 15 years, with Methamphetamine projected at a 475%+ increase. This is concerning as there are more than a million high quality data points over 5 years and an R2 value of 90%+ which paints of picture of statistical certainty. This shows that the opioid crisis has moved from a lift caused by supply side drivers to an organically growing demand side driven pandemic fueled secondarily by histories cheapest and most available synthetic drugs. With $100B+ in fines projected for the opioid crisis in the next few years, state jurisdictions will shortly receive an enormous amount of cash that will be legally obligated to flow into anti-addiction spending. Due to poor outcomes and non-scalable approaches around advanced public health programs, there will be a flurry of legislature to address how to spend the $100B+ anti-addiction warchest. Players like Universal Ibogaine who have proven clinical models, can deploy infrastructure and guarantee statistically better outcomes will receive unprecedented amounts of non-dilutive government funding and will be the first to benefit from Decriminalization/Medicalization in the North American market. Players that can come to the table now at the state level and propose medicalization legislature as well as profitable clinical infrastructure with proven outcomes, could monopolize the entire US market. FieldTrip Ventures is developing Psilocybin clinical infrastructure while Universal Ibogaine is deploying proven clinical infrastructure already developed and proven by Clear Sky Recovery, the leading Ibogaine clinical experts with thousands of successful detox procedures and no critical adverse events.
Closing:
Like any emerging industry, there are challenges and growing pains but the blue-sky upside is unparalleled. "Black swan events are characterized by their extreme rarity, their severe impact, and the practice of explaining widespread failure to predict them as simple folly in hindsight." Due to changes in public opinion, a mental health and addiction pandemic as well as enormous movements of liquid cash, this sector is poised to explode in 2020.
Additional information requests: [[email protected]](mailto:[email protected])
submitted by mindovermatterlondon to shroomstocks [link] [comments]

PPC Restrictions: Approved Food Ltd prohibits all affiliates from bidding on the Approved Food brand name or misspellings for all search engines, display, mobile or any other digital media bidding platforms. This notification applies to, but is not limited to, the Approved Food Ltd. trademarks and brand names, including variations. Earn commissions of 10% simply by applying as an affiliate. and promoting Heather’s Choice products. That’s our lucky 13 inclusion to our best affiliate marketing programs guide. Carry on reading to learn about more programs that you can sign up to or click here to check out other great food & drink affiliate programs. 14. It takes the same amount of time & effort to promote a product that pays you $500 than it does to promote one that pays you only $29. On this site you'll find: - Over 1000 high ticket affiliate programs - More than 100 different affiliate categories - Grouped into 12 market-related modules Affiliate Partners Ltd. is one of the first affiliate networks in the financial industry and is known as the affiliate network with the highest payouts (CPA) up to $600 for niches like trading, gaming, casino, sales funnels and many more. Working with them makes affiliate marketing much easier for you because of their very professional team That’s because 88% of mortgage applications in the United States are approved. Basically, the mortgage industry is booming with thousands of new mortgages being granted every week. And some of the affiliate programs we found for you pay up to $200 per lead. So, you do the math.

[index] [7119] [4429] [616] [11541] [15050] [8976] [5588] [2560] [6486] [4794]